{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:14Z","timestamp":1787015474278,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T00:00:00Z","timestamp":1350604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Type I collagen degradation end\u2010products and related matrix metalloproteinases (\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      s) were examined aiming to detect potential markers of periodontitis in saliva, with high sensitivity and specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The salivary concentrations of\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      \u20108,\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      \u20109 and\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      \u201013, tartrate\u2010resistant acid phosphatase serum type 5b, C\u2010terminal cross\u2010linked telopeptide of type I collagen (\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      x), N\u2010terminal cross\u2010linked telopeptide of type I collagen (\n                      <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\n                      x) and cross\u2010linked carboxyterminal telopeptide of type I collagen were analysed in 230 subjects. Oral health examination included panoramic radiography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The concentrations of\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      \u20108,\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      \u20109 and\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      \u201013 in saliva were higher in subjects with generalized periodontitis than in controls. Of the tested salivary markers,\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      \u20108 was the only marker capable of differentiating subjects with severe alveolar bone loss from those with slight bone loss (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The association between the salivary\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      \u20108 levels and periodontitis remained significant after the adjustment with age, gender and smoking. In addition, significant correlations were found between the tested markers and periodontal parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Enzymes and end\u2010products of type I collagen degradation have different associations with each other and with periodontal status that may reflect their roles in the cascade leading to alveolar bone loss.\n                      <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                      \u20108 is a strong biomarker candidate for detecting alveolar bone destruction.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12020","type":"journal-article","created":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T23:51:09Z","timestamp":1348444269000},"page":"18-25","source":"Crossref","is-referenced-by-count":106,"title":["Salivary type I collagen degradation end\u2010products and related matrix metalloproteinases in periodontitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Ulvi K.","family":"Gursoy","sequence":"first","affiliation":[{"name":"Institute of Dentistry University of Turku Turku Finland"},{"name":"Department of Infectious Disease Surveillance and Control National Institute for Health and Welfare (THL) Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"K\u00f6n\u00f6nen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Turku Turku Finland"},{"name":"Department of Infectious Disease Surveillance and Control National Institute for Health and Welfare (THL) Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisko","family":"Huumonen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina","family":"Tervahartiala","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"},{"name":"Department of Oral &amp; Maxillofacial Surgery Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirkko J.","family":"Pussinen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"},{"name":"Department of Oral &amp; Maxillofacial Surgery Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Suominen","sequence":"additional","affiliation":[{"name":"Unit of Living Conditions, Health and Wellbeing Department of Environmental Health in Environmental Epidemiology Unit National Institute for Health and Welfare (THL) Kuopio Finland"},{"name":"Institute of Dentistry University of Eastern Finland Kuopio Finland"},{"name":"Department of Oral and Maxillofacial Surgery Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"},{"name":"Department of Oral &amp; Maxillofacial Surgery Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.11.5872"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/clinchem\/46.11.1751","article-title":"Rapid screening method for osteoclast differentiation in vitro that measures tartrate\u2010resistant acid phosphatase 5b activity secreted into the culture medium","volume":"46","author":"Alatalo S. 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