{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:33:44Z","timestamp":1787985224299,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This 3\u2010year prospective randomized controlled trial compared the clinical, microbiological and biochemical outcome of minimally (Turned, Tur) and moderately rough (TiUnite<jats:sup>\u00ae<\/jats:sup>, TiU) implant surfaces in a split\u2010mouth design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The study population included 14 subjects: nine fully edentulous and five partially edentulous subjects with a history of periodontitis. Implants (<jats:italic>n<\/jats:italic>\u00a0=\u00a078, 39 Tur and 39 TiU) were installed randomly in each patient. Peri\u2010implant clinical parameters and intra\u2010oral radiographs were recorded after 3\u00a0years of loading. Subgingival plaque and peri\u2010implant crevicular fluid samples were collected and analysed using culture and quantitative polymerase chain reaction for the biofilm, and enzyme\u2010linked immunosorbent assay for the concentration of osteoprotegerin and receptor activator of nuclear factor kappa\u2010B ligand, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences in clinical, microbiological and biochemical parameters could be observed when comparing the Tur and TiU implant surfaces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After 3\u00a0years of loading, in periodontitis susceptible patients, the moderately rough, TiU implants demonstrated a similar clinical outcome compared with the smoother, turned implants. Longer follow\u2010up and studies using different implant types are needed to confirm the statement that minimally and moderately rough implant surfaces perform similar, both from a clinical and from a microbiological point of view.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12022","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T03:55:07Z","timestamp":1348458907000},"page":"1183-1190","source":"Crossref","is-referenced-by-count":22,"title":["<scp>RCT<\/scp> comparing implants with turned and anodically oxidized surfaces: A pilot study, a 3\u2010year follow\u2010up"],"prefix":"10.1111","volume":"39","author":[{"given":"Elena A.","family":"Nicu","sequence":"first","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Van Assche","sequence":"additional","affiliation":[{"name":"Department of Periodontology Catholic University Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Coucke","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology Scientific Institute of Public Health Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Teughels","sequence":"additional","affiliation":[{"name":"Department of Periodontology Catholic University Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Quirynen","sequence":"additional","affiliation":[{"name":"Department of Periodontology Catholic University Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01589.x"},{"key":"e_1_2_6_3_1","first-page":"536","article-title":"Oral implant surfaces: part 1\u2013review focusing on topographic and chemical properties of different surfaces and in vivo responses to them","volume":"17","author":"Albrektsson T.","year":"2004","journal-title":"International Journal of Prosthodontics"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01396.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01165.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01274.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1989.tb00863.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2004.tb00213.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2000.tb00007.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0109-5641(97)80038-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.070302.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01815.x"},{"key":"e_1_2_6_13_1","first-page":"289","article-title":"Attachment and growth of periodontal cells on smooth and rough titanium","volume":"9","author":"Cochran D. 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