{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:46:05Z","timestamp":1785800765891,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T00:00:00Z","timestamp":1352073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This split\u2010mouth double\u2010masked randomized controlled clinical study evaluated the effectiveness of photoactivated disinfection (<jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>) using light\u2010emitting diode (<jats:styled-content style=\"fixed-case\">LED<\/jats:styled-content>) as an adjunct in the management of patients affected by moderate to severe chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Sixteen patients affected by moderate to severe chronic periodontitis were enrolled. After scaling and root planing (SRP), each quadrant was assigned to one of the following groups: LED group (625\u2013635\u00a0nm, maximum power density: 2000\u00a0mW\/cm<jats:sup>2<\/jats:sup>), photosensitizer group (tolouidine blue O, 0.1\u00a0mg\/ml), PAD group (photosensitizer and LED) and control group (no adjunctive treatment). The adjunctive treatments were repeated after 7 and 14\u00a0days. The clinical parameters of bleeding on probing, probing pocket depth and clinical attachment level were measured at baseline and 1 and 3\u00a0months after SRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1 and 3\u00a0months, all groups showed significant improvements with regard to all clinical parameters compared to baseline (all <jats:italic>p<\/jats:italic>: &lt;0.001). There were no significant differences among groups in terms of changes of clinical parameters in any time interval (all <jats:italic>p\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The application of <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content> using <jats:styled-content style=\"fixed-case\">LED<\/jats:styled-content> with the current setting did not have additional effects on clinical parameters in patients diagnosed with moderate to severe chronic periodontitis compared with <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12024","type":"journal-article","created":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T08:59:46Z","timestamp":1348822786000},"page":"65-72","source":"Crossref","is-referenced-by-count":69,"title":["Photoactivated disinfection using light\u2010emitting diode as an adjunct in the management of chronic periodontitis: a pilot double\u2010blind split\u2010mouth randomized clinical trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Seyed H.","family":"Bassir","sequence":"first","affiliation":[{"name":"Laser Research Center in Dentistry Tehran University of Medical Science Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Moslemi","sequence":"additional","affiliation":[{"name":"Laser Research Center in Dentistry Advanced Periodontics, School of Dentistry Tehran University of Medical Science Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raika","family":"Jamali","sequence":"additional","affiliation":[{"name":"Student's Scientific Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Mashmouly","sequence":"additional","affiliation":[{"name":"Laser Research Center in Dentistry School of Dentistry Tehran University of Medical Science Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Fekrazad","sequence":"additional","affiliation":[{"name":"Laser Research Center in Dentistry Advanced Periodontics, School of Dentistry Tehran University of Medical Science Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Chiniforush","sequence":"additional","affiliation":[{"name":"Laser Research Center in Dentistry School of Dentistry Tehran University of Medical Science Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad R.","family":"Shamshiri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hessam","family":"Nowzari","sequence":"additional","affiliation":[{"name":"Professor of Clinical Dentistry and Director of Advanced Periodontics Herman Ostrow School of Dentistry University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"34","article-title":"Treatment of periodontal disease by photodisinfection compared to scaling and root planing","volume":"18","author":"Andersen R.","year":"2007","journal-title":"The Journal of clinical dentistry"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-009-0744-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090285"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02024.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01303.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2969"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-008-0565-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070652"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.443"},{"issue":"2","key":"e_1_2_7_12_1","first-page":"6","article-title":"Clinical significance of non\u2010surgical periodontal therapy: an evidence\u2010based perspective of scaling and root planing","volume":"29","author":"Cobb C. 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