{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:31:50Z","timestamp":1789810310326,"version":"4.0.1"},"reference-count":76,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ETEP Research group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To update the existing scientific evidence on the efficacy of local antimicrobials as adjuncts to subgingival debridement in the treatment of chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Fifty\u2010six papers were selected, reporting data from 52 different investigations. All the studies reported changes in probing pocket depth (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) and clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) and most in plaque index (PlI) and\/or bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>). Meta\u2010analyses were performed with the data retrieved from the studies fulfilling the inclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall effect of the subgingival application of antimicrobials was statistically significant (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.000) for both changes in <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> with a weighted mean difference (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>) of \u22120.407 and \u22120.310\u00a0mm respectively. No significant differences occurred for changes in <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> and PlI. Subgingival application of tetracycline fibres, sustained released doxycycline and minocycline demonstrated a significant benefit in <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> reduction (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> between 0.5 and 0.7\u00a0mm). The rest of the tested outcomes demonstrated a high heterogeneity. The local application of chlorhexidine and metronidazole showed a minimal effect when compared with placebo (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> between 0.1 and 0.4\u00a0mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The scientific evidence supports the adjunctive use of local antimicrobials to debridement in deep or recurrent periodontal sites, mostly when using vehicles with proven sustained release of the antimicrobial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12026","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T13:20:06Z","timestamp":1349011206000},"page":"227-241","source":"Crossref","is-referenced-by-count":152,"title":["A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Paula","family":"Matesanz\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Garc\u00eda\u2010Gargallo","sequence":"additional","affiliation":[{"name":"Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Figuero","sequence":"additional","affiliation":[{"name":"Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bascones\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"},{"name":"\u201cHost Response in Oral and Periodontal Pathology\u201d Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Herrera","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2006.00174.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00457.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.46.25"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.6.608"},{"key":"e_1_2_10_6_1","first-page":"11","article-title":"Association of antimicrobial and clinical efficacy: periodontitis therapy with minocycline microspheres","volume":"12","author":"Bland P. S.","year":"2010","journal-title":"Journal of the International Academy of Periodontology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070515"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.8.1227"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01461.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060122"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050216"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00751.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050220"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060221"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01003.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.8.692"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290204.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.1.13"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060488"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.55844"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01838.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2000.0087"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027012910.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291001.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5005\/jcdp-9-7-25","article-title":"Comparative evaluation of subgingivally delivered 10% doxycycline hyclate and xanthan\u2010based chlorhexidine gels in the treatment of chronic periodontitis","volume":"9","author":"Gupta R.","year":"2008","journal-title":"Journal of Contemporary Dental Practice"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00765.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.115"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.79"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2001.280114.x"},{"key":"e_1_2_10_30_1","first-page":"77","article-title":"Scaling and root\u2010planing treatment with adjunctive subgingival minocycline. A clinical pilot study over six months, of sites adjacent to and remote from the antibiotic application","volume":"4","author":"Henderson R. J.","year":"2002","journal-title":"Journal of the International Academy of Periodontology"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01260.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.8.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-985X.2008.00552.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291102.x"},{"key":"e_1_2_10_35_1","first-page":"51","article-title":"Clinical and microbiological effects of topical minocycline in the treatment of elderly patients with periodontitis","volume":"183","author":"Jarrold C. R.","year":"1997","journal-title":"British Dental Journal"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.9.989"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.2.256"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.9.840"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.11.1058"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2007.00255.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s2.2.x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.1"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.7.819"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.464"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050087"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.2.167"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb00430.x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050105"},{"key":"e_1_2_10_49_1","first-page":"63","article-title":"Clinical and microbiological study of local minocycline delivery (Periocline) following scaling and root planing in recurrent periodontal pockets","volume":"32","author":"Nakagawa T.","year":"1991","journal-title":"Bulletin of Tokyo Dental College"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.7.685"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00485.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4809695"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260305.x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070308"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090050"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01173.x"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070589"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280104.x"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.9.860"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.t01-2-261101.x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00493.x"},{"key":"e_1_2_10_62_1","first-page":"20","article-title":"Clinical and microbiological effects of adjunctive, locally delivered chlorhexidine on patients with chronic periodontitis","volume":"12","author":"Sakellari D.","year":"2010","journal-title":"Journal of the International Academy of Periodontology"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01256.x"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02407.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1902\/jop.1997.68.1.32","article-title":"Sustained local delivery of chlorhexidine in the treatment of periodontitis: a multi\u2010center study","volume":"68","author":"Soskolne W. A.","year":"1997","journal-title":"Journal of Periodontology"},{"key":"e_1_2_10_66_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1902\/jop.1993.64.7.637","article-title":"Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: a randomized, double\u2010blind, vehicle\u2010controlled, multicenter study","volume":"64","author":"Steenberghe D.","year":"1993","journal-title":"Journal of Periodontology"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027006447.x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02064.x"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00599.x"},{"key":"e_1_2_10_70_1","first-page":"15","article-title":"Preferred reporting items for systematic reviews and meta\u2010analyses: the PRISMA statement","volume":"47","author":"Tob\u00edas A.","year":"2008","journal-title":"Stata Techical Bulletin"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02514.x"},{"key":"e_1_2_10_72_1","first-page":"72","article-title":"Enhancing the value of scaling and root\u2010planing: Arestin clinical trial results","volume":"4","author":"Van Dyke T. E.","year":"2002","journal-title":"Journal of the International Academy of Periodontology"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.8s.772"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2001.280806.x"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1535"},{"key":"e_1_2_10_76_1","first-page":"490","article-title":"Clinical response of localized recurrent periodontitis treated with scaling, root planing, and tetracycline fiber","volume":"97","author":"Wong M. Y.","year":"1998","journal-title":"Journal of the Formosan Medical Association"},{"key":"e_1_2_10_77_1","first-page":"23","article-title":"Evaluation of adjunctive tetracycline fiber therapy with scaling and root planing: short\u2010term clinical results","volume":"21","author":"Yalcin F.","year":"1999","journal-title":"Periodontal Clinical Investigations"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12026","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T06:32:25Z","timestamp":1700634745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,16]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/jcpe.12026"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12026","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,16]]}}}