{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:29:59Z","timestamp":1776284999037,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of modified minimally invasive surgical technique (M\u2010<jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content>) technique with local delivery of recombinant human platelet derived growth factor (rh<jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>) gel in the treatment of intrabony defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010four healthy subjects were included in the present double\u2010blinded, randomized, controlled study. Test group was treated with M\u2010<jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content> and rh<jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content> and control group with M\u2010<jats:styled-content style=\"fixed-case\">MIST<\/jats:styled-content> alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) and gingival recession, cementoenamel junction to base of the defect (<jats:styled-content style=\"fixed-case\">CEJ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>), defect depth (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>) and cementoenamel junction to alveolar crest (<jats:styled-content style=\"fixed-case\">CEJ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>), at baseline to 6\u00a0months post\u2010operatively in both the groups were statistically significant. Inter\u2010group comparison for gain in attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>\u2010G), probing depth reduction (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010R) and change in gingival margin position linear bone growth (<jats:styled-content style=\"fixed-case\">LBG<\/jats:styled-content>), percentage bone fill, residual defect depth (residual <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>) and the change in alveolar crest position revealed no statistically significant differences. Gain in <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LBG<\/jats:styled-content> was 3\u00a0\u00b1\u00a00.89\u00a0mm and 1.89\u00a0\u00b1\u00a00.6 in test group and 2.64\u00a0\u00b1\u00a00.67\u00a0mm and 1.85\u00a0\u00b1\u00a01.18\u00a0mm in control group, respectively, and did not show statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The improvement in both groups could be attributed to the novel surgical technique rather than addition of rh<jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12030","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T08:21:43Z","timestamp":1353486103000},"page":"172-179","source":"Crossref","is-referenced-by-count":42,"title":["Efficacy of modified minimally invasive surgical technique in the treatment of human intrabony defects with or without use of rhPDGF\u2010BB gel \u2013 a randomized controlled trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Ashank","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Periodontics Sri Sai College of Dental Surgery Vikarabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haritha","family":"Avula","sequence":"additional","affiliation":[{"name":"Department of Periodontics Sri Sai College of Dental Surgery Vikarabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnajaneya R.","family":"Pathakota","sequence":"additional","affiliation":[{"name":"Department of Periodontics Sri Sai College of Dental Surgery Vikarabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayakumar","family":"Avula","sequence":"additional","affiliation":[{"name":"Department of Periodontics Sri Sai College of Dental Surgery Vikarabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_3_1","first-page":"213","article-title":"Periodontal regeneration in human Class II furcations using purified recombinant human platelet\u2010derived growth factor\u2010BB (rhPDGF\u2010BB) with bone allograft","volume":"23","author":"Camelo M.","year":"2003","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01242.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.4.254"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01020.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01144.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01352.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01705.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.399"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01451.x"},{"key":"e_1_2_6_12_1","volume-title":"Clinical Periodontology","author":"Glickman I.","year":"1953"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00374.x"},{"key":"e_1_2_6_14_1","first-page":"960","article-title":"Granulation tissue removal in routine and minimally invasive procedures","volume":"16","author":"Harrel S. K.","year":"1995","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_6_15_1","first-page":"E088","article-title":"Microscope\u2010enhanced periodontal therapy: A review and report of four cases","volume":"10","author":"Hegde R.","year":"2009","journal-title":"The Journal of Contemporary Dental Practice"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.12.1186"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.5.651"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01639.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/cap.2011.110038"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01576.x"},{"key":"e_1_2_6_21_1","first-page":"68","volume-title":"Guided periodontal tissue regeneration","author":"Laurell L.","year":"1995"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.3.303"},{"key":"e_1_2_6_23_1","first-page":"3","article-title":"A modified gingival index for use in clinical trials","volume":"8","author":"Lobene R. R.","year":"1986","journal-title":"Clinical Preventive Dentistry"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.6.515"},{"key":"e_1_2_6_25_1","first-page":"40","article-title":"Decalcified freeze\u2010dried bone allograft as an implant material in human periodontal defects","volume":"4","author":"Mellonig J. T.","year":"1984","journal-title":"The International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_26_1","first-page":"103","volume-title":"Textbook of Periodontia (Oral Medicine)","author":"Miller S. C.","year":"1943"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00664.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.9.1282"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2205"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.6.462"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb00888.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb00895.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100680"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100454"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1959.30.1.7"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01539.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100170209"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290407.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00555.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.10.633"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.2.177"},{"key":"e_1_2_6_43_1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1080\/19424396.2004.12224054","article-title":"Minimally invasive surgery: an alternative approach for periodontal and implant reconstruction","volume":"32","author":"Zadeh H. H.","year":"2004","journal-title":"Journal of the California Dental Association"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T04:01:50Z","timestamp":1698638510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/jcpe.12030"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12030","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}