{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:05:05Z","timestamp":1791605105073,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T00:00:00Z","timestamp":1354579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The objective of this randomized, double\u2010blind, placebo\u2010controlled trial was to study the effect of implant surface decontamination with chlorhexidine (<jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>)\/cetylpyridinium chloride (<jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>) on microbiological and clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material &amp; Methods<\/jats:title><jats:p>Thirty patients (79 implants) with peri\u2010implantitis were treated with resective surgical treatment consisting of apically re\u2010positioned flap, bone re\u2010contouring and surface debridement and decontamination. Patients were randomly allocated to decontamination with 0.12% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\u00a0+\u00a00.05% <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> (test\u2010group) or a placebo\u2010solution (without <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>, placebo\u2010group). Microbiological parameters were recorded during surgery; clinical and radiographical parameters were recorded before (pre\u2010) treatment (baseline), and at 3, 6 and 12\u00a0months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine implants in two patients in the placebo\u2010group were lost due to severe persisting peri\u2010implantitis. Both decontamination procedures resulted in significant reductions of bacterial load on the implant surface, but the test\u2010group showed a significantly greater reduction than the placebo\u2010group (log 4.21\u00a0\u00b1\u00a01.89 <jats:italic>versus<\/jats:italic> log 2.77\u00a0\u00b1\u00a02.12, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.006). Multilevel analysis showed no differences between both groups in the effect of the intervention on bleeding, suppuration, probing pocket depth and radiographical bone loss over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Implant surface decontamination with 0.12% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\u00a0+\u00a00.05% <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> in resective surgical treatment of peri\u2010implantitis leads to a greater immediate suppression of anaerobic bacteria on the implant surface than a placebo\u2010solution, but does not lead to superior clinical results. The long\u2010term microbiological effect remains unknown.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12034","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T14:51:16Z","timestamp":1351263076000},"page":"186-195","source":"Crossref","is-referenced-by-count":85,"title":["Implant decontamination during surgical peri\u2010implantitis treatment: a randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Yvonne C. M.","family":"de Waal","sequence":"first","affiliation":[{"name":"Center for Dentistry and Oral Hygiene University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry M.","family":"Raghoebar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J. R.","family":"Huddleston Slater","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene University Medical Center Groningen University of Groningen Groningen The Netherlands"},{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henny J. A.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene University Medical Center Groningen University of Groningen Groningen The Netherlands"},{"name":"Department of Oral and Maxillofacial Surgery University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin G.","family":"Winkel","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie Jan","family":"van Winkelhoff","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene University Medical Center Groningen University of Groningen Groningen The Netherlands"},{"name":"Department of Medical and Oral Microbiology University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01434.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00767493"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-006-0094-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01839.x"},{"key":"e_1_2_5_6_1","first-page":"79","article-title":"Conventional versus CO2 laser\u2010assisted treatment of peri\u2010implant defects with the concomitant use of pure\u2010phase beta\u2010tricalcium phosphate: a 5\u2010year clinical report","volume":"22","author":"Deppe H.","year":"2007","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004970.pub5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2007.09.012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01908.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02276.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00341.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00105.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1574-6968.1992.tb05705.x","article-title":"The mechanism of action of chlorhexidine","volume":"79","author":"Kuyyakanond T.","year":"1992","journal-title":"FEMS Microbiology Letters"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.10.1415"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01283.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01618.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.004"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050601"},{"key":"e_1_2_5_19_1","first-page":"588","article-title":"Efficacy of cetylpyridinium chloride used as oropharyngeal antiseptic","volume":"51","author":"Pitten F. 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