{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:00:27Z","timestamp":1770883227588,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"S\u00e3o Paulo State Research Foundation","award":["09687\/09687-009687\/11419-4"],"award-info":[{"award-number":["09687\/09687-009687\/11419-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this randomized controlled clinical trial was to evaluate the clinical effects of chlorhexidine (<jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>) application in a full\u2010mouth disinfection (<jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>) protocol in poorly controlled type\u20102 diabetic subjects with generalized chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Thirty\u2010eight subjects were randomly assigned into <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> group (<jats:italic>n<\/jats:italic>=19): full\u2010mouth scaling and root planing (<jats:styled-content style=\"fixed-case\">FMSRP<\/jats:styled-content>) within 24\u00a0h + local application of <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> gel + <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> rinses for 60\u00a0days or Control group (<jats:italic>n\u00a0<\/jats:italic>=\u00a019): <jats:styled-content style=\"fixed-case\">FMSRP<\/jats:styled-content> within 24\u00a0h + local application of placebo gel + placebo rinses for 60\u00a0days. Clinical parameters, glycated haemoglobin and fasting plasma glucose were assessed at baseline, 3, 6 and 12\u00a0months post\u2010therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All clinical parameters improved significantly at 3, 6 and 12\u00a0months post\u2010therapies for both groups (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05). There were no significant differences between groups for any clinical parameters, and glycemic condition at any time\u2010point (<jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The treatments did not differ with respect to clinical parameters, including the primary outcome variable (i.e. changes in clinical attachment level in deep pockets), for up to 12\u00a0months post\u2010treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12040","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T10:26:35Z","timestamp":1352283995000},"page":"155-162","source":"Crossref","is-referenced-by-count":34,"title":["Full\u2010mouth disinfection as a therapeutic protocol for type\u20102 diabetic subjects with chronic periodontitis: Twelve\u2010month clinical outcomes. A randomized controlled clinical trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Vanessa R.","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadson A.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamires S.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago E. D.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciene C.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Faveri","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poliana M.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01564.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090544"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01498.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2008.03.006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01239.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.2.123"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00994.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01471.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.8.713"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401212"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01002.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01445.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00658.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01652.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01257.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5005\/jcdp-9-5-9","article-title":"Alterations in HbA1c following minimal or enhanced non\u2010surgical, non\u2010antibiotic treatment of gingivitis or mild periodontitis in type\u20102 diabetic patients: a pilot trial","volume":"9","author":"Madden T. 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