{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:45:50Z","timestamp":1760888750593},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Periodontal diseases are associated with a variety of systemic diseases, including cardiovascular disease and stroke, and patients with periodontitis demonstrate elevated levels of anti\u2010cardiolipin antibodies. We sought to determine if anti\u2010cardiolipin antibodies from periodontitis patients induced monocyte chemotactic protein\u20101 production by human vascular endothelial cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>IgG was purified from sera from 53 subjects, including chronic and aggressive periodontitis patients and periodontally healthy controls, with elevated or normal IgG anti\u2010cardiolipin levels. In addition, anti\u2010cardiolipin antibodies were specifically removed from some sera by immunoabsorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that, irrespective of diagnostic category, IgG from subjects with elevated anti\u2010cardiolipin induced significantly greater monocyte chemotactic protein\u20101 production by human vascular endothelial cells than IgG from those subjects with normal anti\u2010cardiolipin titres. Removal of anti\u2010cardiolipin from IgG preparations from periodontitis patients significantly reduced their ability to induce monocyte chemotactic protein\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Since elevated titres of anti\u2010cardiolipin are found in a significantly greater proportion of patients with periodontitis than in periodontally healthy individuals, and these antibodies activate endothelial cells to produce monocyte chemotactic protein\u20101, they may explain some of the associations noted between periodontal infections and systemic conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12043","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T12:20:10Z","timestamp":1352722810000},"page":"212-217","source":"Crossref","is-referenced-by-count":10,"title":["Anti\u2010cardiolipin from periodontitis patients induces <scp>MCP<\/scp>\u20101 production by human umbilical vein endothelial cells"],"prefix":"10.1111","volume":"40","author":[{"given":"Harvey A.","family":"Schenkein","sequence":"first","affiliation":[{"name":"Department of Periodontics School of Dentistry Virginia Commonwealth University Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sabatini","sequence":"additional","affiliation":[{"name":"Department of Periodontics School of Dentistry Virginia Commonwealth University Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Koertge","sequence":"additional","affiliation":[{"name":"Department of Periodontics School of Dentistry Virginia Commonwealth University Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol N.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Periodontics School of Dentistry Virginia Commonwealth University Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald B.","family":"Purkall","sequence":"additional","affiliation":[{"name":"Department of Periodontics School of Dentistry Virginia Commonwealth University Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000078603.90302.4A"},{"key":"e_1_2_6_3_1","first-page":"S27","article-title":"Role of infectious agents in systemic rheumatic diseases","volume":"26","author":"Amital H.","year":"2008","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.03.002"},{"key":"e_1_2_6_6_1","first-page":"S18","article-title":"Infections, connective tissue diseases and vasculitis","volume":"26","author":"Avcin T.","year":"2008","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1172\/JCI0212337","article-title":"Bacterial induction of autoantibodies to beta2\u2010glycoprotein\u2010I accounts for the infectious etiology of antiphospholipid syndrome","volume":"109","author":"Blank M.","year":"2002","journal-title":"The Journal of clinical investigation"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.8.4209"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-008-8103-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10130"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.101535"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1361.086"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31825719f3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308093553"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310382429"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(93)90242-G"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/096120339400300408"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1055\/s-0038-1649940","article-title":"Induction of thrombosis in a mouse model by IgG, IgM and IgA immunoglobulins from patients with the antiphospholipid syndrome","volume":"74","author":"Pierangeli S. 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