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The periodontal defects were treated with osseous resective surgery, and the flap design included both the periodontal pockets and the neighbouring inter\u2010proximal healthy sites. Pocket\u2010associated and healthy tissues were harvested for proteomic analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen proteins were differently expressed between pathological and healthy tissues. In particular, annexin A2, actin cytoplasmic 1, carbonic anhydrase 1 &amp; 2; Ig kappa chain C region (two spots) and flavinreductase were overexpressed, whereas 14\u20103\u20103 protein sigma and zeta\/delta, heat\u2010shock protein beta \u20101 (two spots), triosephosphateisomerase, peroxiredoxin\u20101, fatty acid\u2010binding protein\u2010epidermal, and galectin\u20107 were underexpressed in pathological tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The unbalanced functional network of proteins involved could hinder adequate tissue response to pathogenic noxa. The study of periodontal pocket tissue proteomic profile would be crucial to better understand the pathogenesis of and the therapeutic strategies for periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12050","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T10:55:25Z","timestamp":1354791325000},"page":"573-582","source":"Crossref","is-referenced-by-count":37,"title":["Non\u2010bacterial protein expression in periodontal pockets by proteome analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"Carlo","family":"Bertoldi","sequence":"first","affiliation":[{"name":"Department of Surgery Medicine Dentistry and Morphological Sciences with Transplant Surgery Oncology and Regenerative Medicine Relevance University of Modena and Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Bellei","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of 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