{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:26:14Z","timestamp":1770697574510,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the 1\u2010year clinical and microbiological outcomes of an enhanced anti\u2010infective therapy with versus without systemic antimicrobials in patients with generalized aggressive periodontitis (GAP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this 12\u2010month randomized, double\u2010blinded, placebo\u2010controlled trial, 35 individuals assigned to a control (<jats:italic>n<\/jats:italic>\u00a0=\u00a017) or test group (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) received full\u2010mouth supra and subgingival ultrasonic debridement followed by scaling and root planing with chlorhexidine rinsing, brushing, and irrigation. Subjects received either amoxicillin (AMX, 500\u00a0mg) + metronidazole (MET, 250\u00a0mg) or placebos, TID for 10\u00a0days. Subgingival samples were obtained and analysed for their composition by checkerboard. Data were subjected to non\u2010parametric tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both therapeutic protocols resulted in similar significant clinical improvement for most parameters at 1 year (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). The AMX + MET group exhibited shallower residual pockets than the placebo (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.05). Most periodontal pathogens decreased, whereas beneficial bacteria increased in counts in both groups over time (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0012). High levels of some periodontal and other microbial pathogens were associated with disease persistence regardless treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The enhanced anti\u2010infective mechanical therapy is comparable with its combination with systemic AMX+MET for most clinical parameters and for maintaining low levels of periodontal pathogens for up to 1 year after treatment of GAP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12052","type":"journal-article","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T10:24:40Z","timestamp":1355135080000},"page":"242-251","source":"Crossref","is-referenced-by-count":30,"title":["Clinical and microbiological effects of systemic antimicrobials combined to an anti\u2010infective mechanical debridement for the management of aggressive periodontitis: a 12\u2010month randomized controlled trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Mayra Xavier 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