{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:08:02Z","timestamp":1780445282453,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T00:00:00Z","timestamp":1360022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo a pesquisa do Estado de S\u00e3o Paulo FAPESP","award":["08\/56358-2"],"award-info":[{"award-number":["08\/56358-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To clinically evaluate proximal furcations treated with hydroxyapatite\/\u03b2\u2010tricalcium phosphate (HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content>) isolated or combined with enamel matrix derivative (EMD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>Thirty patients, presenting at least one proximal class II furcation defect, probing pocket depth (PPD<\/jats:styled-content>) \u22655\u00a0mm and bleeding on probing, were included. The defects were assigned to the HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content> group (n<\/jats:italic>\u00a0=\u00a015); open\u2010flap debridement (OFD<\/jats:styled-content>)\u00a0+\u00a0HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content> filling, or, HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content>\u2010EMD<\/jats:styled-content> group (n<\/jats:italic>\u00a0=\u00a015); OFD<\/jats:styled-content>\u00a0+\u00a0HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content>\u00a0+\u00a0EMD<\/jats:styled-content> filling. Plaque (PI<\/jats:styled-content>) and gingival index (GI<\/jats:styled-content>), PPD<\/jats:styled-content>, relative gingival margin position (RGMP<\/jats:styled-content>), vertical and horizontal attachment level (RVAL<\/jats:styled-content> and RHAL<\/jats:styled-content>), vertical and horizontal bone level (RVBL<\/jats:styled-content> and RHBL<\/jats:styled-content>), and furcation diagnosis were evaluated at baseline and at 6\u00a0months.<\/jats:p><\/jats:sec>Results<\/jats:title>Both groups presented improvements after therapies (p<\/jats:italic>\u00a0<\u00a00.05); however, no inter\u2010group differences could be seen in any single parameter (p<\/jats:italic>\u00a0>\u00a00.05). At 6\u00a0months, the gains in rVCAL<\/jats:styled-content> in the HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content> and HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content>\u2010EMD<\/jats:styled-content> groups were 1.47\u00a0\u00b1\u00a00.99 and 2.10\u00a0\u00b1\u00a00.87\u00a0mm, while the RHCAL<\/jats:styled-content> gains were 1.47\u00a0\u00b1\u00a01.46 and 1.57\u00a0\u00b1\u00a01.58\u00a0mm (p<\/jats:italic>\u00a0>\u00a00.05). The RVBL<\/jats:styled-content> and RHBL<\/jats:styled-content> gains for the HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content> and HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content>\u2010EMD<\/jats:styled-content> group were 1.47\u00a0\u00b1\u00a01.13 and 1.70\u00a0\u00b1\u00a01.26\u00a0mm, and 1.90\u00a0\u00b1\u00a01.11 and 1.70\u00a0\u00b1\u00a01.37\u00a0mm respectively (p<\/jats:italic>\u00a0>\u00a00.05). The HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content>\u2010EMD<\/jats:styled-content> group showed seven closed furcations versus four in the HA<\/jats:styled-content>\/\u03b2\u2010TCP<\/jats:styled-content> group (p<\/jats:italic>\u00a0>\u00a00.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Both treatments lead to improvements in all clinical variables studied in the present trial. However, the closure of proximal class II furcation defects is still unpredictable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12054","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T07:03:51Z","timestamp":1355295831000},"page":"252-259","source":"Crossref","is-referenced-by-count":33,"title":["Hydroxyapatite\/\u03b2\u2010tricalcium phosphate and enamel matrix derivative for treatment of proximal class II furcation defects: a randomized clinical trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Maria F. S.","family":"Peres","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Periodontics Piracicaba Dental School UNICAMP S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rica D. P.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Periodontics Bahian Foundation for Development of Science Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato C. V.","family":"Casarin","sequence":"additional","affiliation":[{"name":"Division of Periodontics UNIP Paulista University Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina G. S.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics Piracicaba Dental School UNICAMP S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco H. 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