{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:58:21Z","timestamp":1780084701300,"version":"3.54.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Georgia Health Sciences University College"},{"name":"US Army Advanced Education Program"},{"name":"Georgia Health Sciences College of Dental Medicine"},{"name":"Nobel Biocare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The objective of this research was to elucidate early events in periodontal wound healing\/regeneration using histological and immunohistochemical techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Routine critical\u2010size, supraalveolar, periodontal defects including a space\u2010providing titanium mesh device were created in 12 dogs. Six animals received additional autologous blood into the defect prior to wound closure. One animal from each group was killed for analysis at 2, 5, 9, 14\u00a0days, and at 4 and 8\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups behaved similarly. Periodontal wound healing\/regeneration progressed through three temporal phases. Early phase (2\u20135\u00a0days): heterogeneous clot consolidation and cell activation in the periodontal ligament (<jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content>) and trabecular bone was associated with <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content> regeneration and formation of a pre\u2010osteoblast population. Intermediate phase (9\u201314\u00a0days): cell proliferation (shown by <jats:styled-content style=\"fixed-case\">PCNA<\/jats:styled-content> immunostaining)\/migration led to osteoid\/bone, <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content> and cementum formation. Late phase (4\u20138\u00a0weeks): primarily characterized by tissue remodelling\/maturation. Fibrous connective tissue from the gingival mucosa entered the wound early, competing with regeneration. By day 14, the wound space was largely filled with regenerative and reparative tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Activation of cellular regenerative events in periodontal wound healing\/regeneration is rapid; the general framework for tissue formation is broadly outlined within 14\u00a0days. Most bone formation apparently originates from endosteally derived pre\u2010osteoblasts; the <jats:styled-content style=\"fixed-case\">PDL<\/jats:styled-content> possibly acting as a supplementary source, with a primary function likely being regulatory\/homeostatic. Blood accumulation at the surgical site warrants exploration; supplementation may be beneficial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12055","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T02:06:41Z","timestamp":1356660401000},"page":"527-541","source":"Crossref","is-referenced-by-count":29,"title":["Events of wound healing\/regeneration in the canine supraalveolar periodontal defect model"],"prefix":"10.1111","volume":"40","author":[{"given":"Douglas P.","family":"Dickinson","sequence":"first","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Georgia Regents University College of Dental Medicine Augusta GA USA"},{"name":"Camellix, LLC Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon G.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Georgia Regents University College of Dental Medicine Augusta GA USA"},{"name":"US Army Advanced Education Program in Periodontics Fort Gordon GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Batrice","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Georgia Regents University College of Dental Medicine Augusta GA USA"},{"name":"US Army Advanced Education Program in Periodontics Fort Gordon GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaebum","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Georgia Regents University College of Dental Medicine Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Koli","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Georgia Regents University College of Dental Medicine Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Pennington","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Georgia Regents University College of Dental Medicine Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Susin","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Georgia Regents University College of Dental Medicine Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf M. 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