{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:21:37Z","timestamp":1791426097169,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T00:00:00Z","timestamp":1367798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Application of a synthetic <jats:styled-content style=\"fixed-case\">BMP\u20106<\/jats:styled-content> polypeptide in a rat periodontal fenestration defect model enhanced periodontal wound healing\/regeneration including new bone and cementum formation. The purpose of this study was to translate the relevance of these initial observations into a discriminating large animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Critical\u2010size (4\u20135\u00a0mm) supraalveolar periodontal defects were created at the 2<jats:sup>nd<\/jats:sup> and 3<jats:sup>rd<\/jats:sup> mandibular premolar teeth in 11 Beagle dogs. Experimental sites received <jats:styled-content style=\"fixed-case\">BMP\u20106<\/jats:styled-content> at 0.25, 1.0 and 2.0\u00a0mg\/ml soak\u2010loaded onto an absorbable collagen sponge (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) carrier or <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> alone (control) each condition repeated in four jaw quadrants. The animals were euthanized at 8\u00a0weeks when block biopsies were collected and processed for histologic\/histometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BMP\u20106<\/jats:styled-content> at 0.25, 1.0 and 2.0\u00a0mg\/ml soak\u2010loaded onto the ACS yielded significantly enhanced new bone (0.99\u00a0\u00b1\u00a00.07 <jats:italic>versus<\/jats:italic> 0.23\u00a0\u00b1\u00a00.13\u00a0mm\/BMP\u20106 at 0.25\u00a0mg\/ml) and cementum (2.45\u00a0\u00b1\u00a00.54 <jats:italic>versus<\/jats:italic> 0.73\u00a0\u00b1\u00a00.15\u00a0mm\/BMP\u20106 at 0.25\u00a0mg\/ml) formation including a functionally oriented periodontal ligament compared with control (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). A significant inverse linear association between <jats:styled-content style=\"fixed-case\">BMP\u20106<\/jats:styled-content> dose and new bone (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.21\u00a0\u00b1\u00a00.09\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016) and cementum height (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.34\u00a0\u00b1\u00a00.15\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.023) was observed. Minimal root resorption was observed without significant differences between groups. Ankylosis was not observed for any of the experimental groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Surgical application of <jats:styled-content style=\"fixed-case\">BMP\u20106<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> onto critical\u2010size supraalveolar defects enhanced periodontal wound healing\/regeneration, in particular cementogenesis including a functionally oriented periodontal ligament; the low <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20106 0.25\u00a0mg\/ml concentration apparently providing the most effective dose.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12075","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T17:36:53Z","timestamp":1358444213000},"page":"624-630","source":"Crossref","is-referenced-by-count":30,"title":["Effects of bone morphogenetic protein\u20106 on periodontal wound healing\/regeneration in supraalveolar periodontal defects in dogs"],"prefix":"10.1111","volume":"40","author":[{"given":"Hsien\u2010Chung","family":"Chiu","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry National Defense Medical Center and Tri\u2010Service General Hospital Taipei Taiwan ROC"},{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration (LAPCR) Georgia Health Sciences University College of Dental Medicine Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Yang","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry National Defense Medical Center and Tri\u2010Service General Hospital Taipei Taiwan ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao\u2010Pei","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry National Defense Medical Center and Tri\u2010Service General Hospital Taipei Taiwan ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf M.E.","family":"Wikesj\u00f6","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration (LAPCR) Georgia Health Sciences University College of Dental Medicine Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Susin","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration (LAPCR) Georgia Health Sciences University College of Dental Medicine Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry National Defense Medical Center and Tri\u2010Service General Hospital Taipei Taiwan ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10543400701376480"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-007-0424-8"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.7.5125"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.8.3401"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9843"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.2.129"},{"key":"e_1_2_5_8_1","first-page":"827","article-title":"Vgr\u20101\/BMP\u20106 induces osteoblastic differentiation of pluripotential mesenchymal cells","volume":"6","author":"Gitelman S. 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