{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T07:17:28Z","timestamp":1782544648566,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T00:00:00Z","timestamp":1361404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Assessment of the effect of non\u2010surgical periodontal therapy (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) on serum inflammatory parameters in patients with untreated aggressive (AgP) and chronic (ChP) periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 31 ChP and 29 AgP were examined clinically prior to and 12\u00a0weeks after <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> (subgingival scaling of all pockets within 2\u00a0days) with systemic antibiotics for patients positive for <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (14 AgP, 9 ChP). Blood was sampled prior to, one day, 6, and 12\u00a0weeks after the first <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> visit. Serum elastase, C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), lipopolysaccharide\u2010binding protein (<jats:styled-content style=\"fixed-case\">LBP<\/jats:styled-content>), interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>) 6, 8, and leukocyte counts were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, serum elastase, <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">LBP<\/jats:styled-content> were significantly (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01) higher in AgP than ChP. Serum elastase, <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LBP<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 were significantly (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) elevated one day after scaling in both groups. Both groups showed significant clinical improvement (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). A significant difference was observed regarding change of serum elastase 12\u00a0weeks after <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> between AgP and ChP (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.015). Multiple regression analysis revealed AgP, African origin, and bleeding on probing to be associated with more pronounced elastase reduction. <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> reduction was associated with African origin, systemic antibiotics, and baseline probing pocket depth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> results in serum elastase reduction in AgP but not in ChP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12076","type":"journal-article","created":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T08:53:14Z","timestamp":1358585594000},"page":"327-333","source":"Crossref","is-referenced-by-count":31,"title":["Non\u2010surgical periodontal therapy decreases serum elastase levels in aggressive but not in chronic periodontitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Peter","family":"Eickholz","sequence":"first","affiliation":[{"name":"Department of Periodontology Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Siegelin","sequence":"additional","affiliation":[{"name":"Department of Periodontology Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Scharf","sequence":"additional","affiliation":[{"name":"Department of Periodontology Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Schacher","sequence":"additional","affiliation":[{"name":"Department of Periodontology Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard M.","family":"Oremek","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Centre for Internal Medicine Hospital of the Johann Wolfgang Goethe\u2010University Frankfurt\/Main Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildegund","family":"Sauer\u2010Eppel","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Centre for Internal Medicine Hospital of the Johann Wolfgang Goethe\u2010University Frankfurt\/Main Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Schubert","sequence":"additional","affiliation":[{"name":"Pneumology, Allergology and Cystic Fibrosis, Children's Hospital Hospital of the Johann Wolfgang Goethe\u2010University Frankfurt\/Main Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wohlfeil","sequence":"additional","affiliation":[{"name":"Department of Periodontology Centre for Dental, Oral, and Maxillofacial Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01916.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.060010"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1123"},{"key":"e_1_2_6_6_1","first-page":"263","article-title":"Adjuvantive Antibiotikagabe in der Parodontitistherapie. 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