{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:56:30Z","timestamp":1770753390726,"version":"3.50.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Many studies investigated the role of genetic variants in periodontitis, but few were established as risk factors. We aimed to validate the associations of recent candidate genes in aggressive periodontitis (AgP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We analysed 23 genes in 600 German AgP patients and 1441 controls on the Illumina custom genotyping array Immunochip. We tested a suggestive association in a Dutch and German\/Austrian AgP case\u2010control sample, and a German chronic periodontitis (CP) case\u2010control sample using Sequenom iPlex assays. We additionally tested the common known risk variant rs1333048 of the gene <jats:italic>ANRIL<\/jats:italic> for its association in a Turkish and Italian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the analysed genes gave statistical evidence for association. Upon covariate adjustment for smoking and gender, in the pooled German\u2010Austrian AgP sample, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10 <\/jats:italic><jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> rs6667202 was associated with <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.77 (95% CI\u00a0=\u00a00.6\u20130.95), and in the Dutch AgP sample, adjacent <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10 <\/jats:italic><jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> rs61815643 was associated with <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0009, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.31 (95% CI\u00a0=\u00a01.4\u20103.8). At rs61815643, binding of the transcription factor <jats:styled-content style=\"fixed-case\">PPARG<\/jats:styled-content> was predicted. <jats:italic><jats:styled-content style=\"fixed-case\">ANRIL<\/jats:styled-content><\/jats:italic> rs1333048 was associated in the Turkish sample (<jats:italic>p<\/jats:italic><jats:sub>allelic<\/jats:sub>\u00a0=\u00a00.026, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.67 [95% CI\u00a0=\u00a01.11\u20132.60]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Previous candidate genes carry no susceptibility factors for AgP. Association of <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010<\/jats:italic> rs61815643 with AgP is suggested. <jats:italic><jats:styled-content style=\"fixed-case\">ANRIL<\/jats:styled-content><\/jats:italic> is associated with periodontitis across different populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12092","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T16:38:45Z","timestamp":1359995925000},"page":"563-572","source":"Crossref","is-referenced-by-count":76,"title":["Validation of reported genetic risk factors for periodontitis in a large\u2010scale replication study"],"prefix":"10.1111","volume":"40","author":[{"given":"Arne S.","family":"Schaefer","sequence":"first","affiliation":[{"name":"Institute for Clinical Molecular Biology Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Bochenek","sequence":"additional","affiliation":[{"name":"Institute for Clinical Molecular Biology Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Manke","sequence":"additional","affiliation":[{"name":"Bioinformatics and Deep\u2010Sequencing Unit Max Planck Institute Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Nothnagel","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics and Statistics Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Graetz","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Periodontology Kiel 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and Periodontology University of Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Noack","sequence":"additional","affiliation":[{"name":"Center of Periodontology, Operative and Preventive Dentistry Universit\u00e4t Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Meyle","sequence":"additional","affiliation":[{"name":"Department of Periodontology University Medical Center Giessen and Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Eickholz","sequence":"additional","affiliation":[{"name":"Clinic of Periodontology (Carolinum) Goethe\u2010University Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Trombelli","sequence":"additional","affiliation":[{"name":"Research Center of Periodontal Diseases University of Ferrara 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