{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:15:42Z","timestamp":1768313742397,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies document the therapeutic potential of recombinant human bone morphogenetic protein\u20102 (rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102) in an absorbable collagen sponge (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) carrier for indications in the axial and appendicular skeleton. Nevertheless, the <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> does not comprise structural integrity to adequately support bone formation for onlay indications. The objective of this study was to evaluate local bone formation and osseointegration following surgical implantation of rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 soak\u2010loaded onto a compression resistant matrix (<jats:styled-content style=\"fixed-case\">CRM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Routine, contralateral, critical\u2010size, supraalveolar, peri\u2010implant defects in five adult male Hound Labrador mongrel dogs received 0.8\u00a0mg rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 soak\u2010loaded onto either the <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> (benchmark control) or a <jats:styled-content style=\"fixed-case\">CRM<\/jats:styled-content> (collagen\/<jats:italic>\u03b2<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content>\/hydroxyapatite) followed by submerged wound closure for primary intention healing. The animals were euthanized at 8\u00a0weeks for histologic\/histometric evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Healing was uneventful albeit considerable initial swelling was observed for either treatment. Sites receiving rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">CRM<\/jats:styled-content> showed significantly increased bone area (20.0\u00a0\u00b1\u00a00.9 <jats:italic>versus<\/jats:italic> 12.3\u00a0\u00b1\u00a02.6\u00a0mm<jats:sup>2<\/jats:sup>, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03) and bone density (24.1\u00a0\u00b1\u00a01.4% <jats:italic>versus<\/jats:italic> 14.6\u00a0\u00b1\u00a02.0%, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04) compared with those receiving rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>. There were no significant differences between treatments for new bone height and osseointegration. Woven and lamellar trabecular bone lined with abundant osteoid was observed for all sites. Inconsistent cortex formation confirmed the immature nature of the newly formed bone. Seroma formation was observed for both treatments (80\u2013100% of the animals\/implants). Sites receiving rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">CRM<\/jats:styled-content> showed residual ceramic granules undergoing biodegradation, including accumulation of foamy macrophages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>rh<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">CRM<\/jats:styled-content> supports bone formation of clinically relevant geometry. Longer observation intervals as well as dose variations appear necessary to capture maturation of the newly formed bone, elimination of residual ceramic granules and resolution of seroma formation(s).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12109","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T18:54:11Z","timestamp":1365188051000},"page":"688-697","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of a compression resistant matrix for recombinant human bone morphogenetic protein\u20102"],"prefix":"10.1111","volume":"40","author":[{"given":"Sheldon X.","family":"Lu","sequence":"first","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration (LAPCR) Georgia Regents University College of Dental Medicine Augusta GA USA"},{"name":"U.S. Army Advanced Education Program in Periodontics Fort Gordon GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago","family":"Fiorini","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration (LAPCR) Georgia Regents University College of Dental Medicine Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaebum","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration (LAPCR) Georgia Regents University College of Dental Medicine Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari S.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Hard Tissue Research Laboratory University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda N.","family":"Buxton","sequence":"additional","affiliation":[{"name":"Biologics, Medtronic \u2010 Spinal Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrick C.","family":"Bisch","sequence":"additional","affiliation":[{"name":"U.S. Army Advanced Education Program in Periodontics Fort Gordon GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Dixon","sequence":"additional","affiliation":[{"name":"U.S. Army Advanced Education Program in Periodontics Fort Gordon GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Susin","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration (LAPCR) Georgia Regents University College of Dental Medicine Augusta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf M. 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