{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:23:33Z","timestamp":1790447013197,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T00:00:00Z","timestamp":1367539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effects of non\u2010surgical periodontal treatment on left ventricular mass (<jats:styled-content style=\"fixed-case\">LVM<\/jats:styled-content>), arterial stiffness, systolic and diastolic blood pressure and plasma levels of inflammatory markers (C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), fibrinogen and interleukin\u20106) in refractory hypertension patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>This interventional prospective cohort pilot study included 26 patients (53.6\u00a0\u00b1\u00a08.0\u00a0years old) diagnosed with refractory hypertension and generalized chronic periodontitis. Subjects received non\u2010surgical periodontal treatment according to their needs. Plasma levels of systemic inflammation (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>; fibrinogen and interleukin\u20106) and established cardiovascular risk factors [systolic and diastolic blood pressure (SBP and DBP), left ventricular mass (LVM) and arterial stiffness] were assessed at three time points (baseline, 3\u00a0months after baseline and 6\u00a0months after periodontal therapy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Periodontal therapy significantly reduced all cardiovascular risk markers evaluated. Median values of SBP and DBP were reduced by 12.5\u00a0mmHg and 10.0\u00a0mmHg, respectively, whereas left ventricular mass (LVM) reduced by 12.9\u00a0g and pulse wave velocity reduced by 0.9\u00a0m\/s (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Levels of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106 and fibrinogen lowered by 0.5\u00a0mg\/dl, 1.4\u00a0pg\/dl and 37.5\u00a0mg\/dl (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), respectively, 6\u00a0months after periodontal therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontal therapy significantly reduced levels of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106, fibrinogen, blood pressure, LVM and arterial stiffness, lowering cardiovascular risk in refractory hypertensive 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