{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:13:40Z","timestamp":1784402020328,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effect of photodynamic therapy (PDT) as adjunct to mechanical therapy in furcations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A double\u2010blind, parallel, randomized controlled clinical trial was conducted in subjects presenting class II furcations. The subjects were randomly allocated to a test (PDT; <jats:italic>n\u00a0<\/jats:italic>=\u00a016) or control group (non\u2010activated laser\/only photosensitizer; <jats:italic>n<\/jats:italic>\u00a0=\u00a021). At baseline, 3 and 6\u00a0months, clinical, microbiological and cytokine pattern evaluation was performed. Clinical attachment level was defined as the primary outcome variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical parameters improved after both therapies (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) with no differences between groups at any time point (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). At 6\u00a0months, real\u2010time PCR evaluation showed a decrease in <jats:italic>Porphyromonas gingivalis<\/jats:italic> and <jats:italic>Tannerella forsythia<\/jats:italic> only in the PDT group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) with no inter\u2010group differences. Regarding cytokines, IL\u20104 and IL\u201010 levels increased in both groups at 6\u00a0months. GM\u2010CSF, IL\u20108, IL\u20101\u03b2 and IL\u20106 levels decreased only in the PDT group after 3\u00a0months (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). At 3\u00a0months, inter\u2010group analyses showed that GM\u2010CSF, IFN\u2010\u03b3, IL\u20106 and IL\u20108 levels were lower in the PDT group. At 6\u00a0months, lower IL\u20101\u03b2 levels were also observed in the PDT group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Photodynamic therapy did not promote clinical benefits for class II furcations; however, advantages in local levels of cytokines and a reduction in periodontopathogens were demonstrated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12121","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T18:39:27Z","timestamp":1367951967000},"page":"781-788","source":"Crossref","is-referenced-by-count":59,"title":["Photodynamic therapy in the treatment of class II furcation: a randomized controlled clinical trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Vanessa H.","family":"Luchesi","sequence":"first","affiliation":[{"name":"Dental Research Division School of Dentistry Paulista University S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana P.","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Dental Research Division School of Dentistry Paulista University S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Kolbe","sequence":"additional","affiliation":[{"name":"Dental Research Division School of Dentistry Paulista University S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda V.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Dental Research Division School of Dentistry Paulista University S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato C.","family":"Casarin","sequence":"additional","affiliation":[{"name":"Dental Research Division School of Dentistry Paulista University S\u00e3o Paulo S\u00e3o Paulo 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