{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:37:24Z","timestamp":1792179444012,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T00:00:00Z","timestamp":1378080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","award":["2009\/16016-8"],"award-info":[{"award-number":["2009\/16016-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"name":"3M Non-Tenured Faculty"},{"name":"Nobel Biocare AB"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the effect of recombinant human bone morphogenetic protein\u20102 (rhBMP\u20102) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior maxilla.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four subjects were enrolled in a randomized, controlled, parallel\u2010group, open\u2010label clinical trial. Subjects either received rhBMP\u20102\/ACS (1.5\u00a0mg\/ml) or particulated autogenous bone harvested from the mandibular retromolar region. A titanium\u2010mesh was used to provide space and wound stability. A guide was used to standardize clinical recordings using an analogue caliper. Alveolar ridge width was also assessed using cone\u2010beam computed tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>rhBMP\u20102\/ACS yielded significantly greater radiographic horizontal bone gain compared with autogenous bone graft at immediate subcrestal levels (1.5\u00a0\u00b1\u00a00.7 <jats:italic>versus<\/jats:italic> 0.5\u00a0\u00b1\u00a00.9\u00a0mm; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01); non\u2010significant differences were observed at mid\u2010 (2.9\u00a0\u00b1\u00a00.8 <jats:italic>versus<\/jats:italic> 2.9\u00a0\u00b1\u00a00.9\u00a0mm; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.98) and apical (1.7\u00a0\u00b1\u00a00.9 <jats:italic>versus<\/jats:italic> 1.8\u00a0\u00b1\u00a01.1\u00a0mm; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.85) crestal levels. No significant differences in clinical horizontal bone gain were observed at 6\u00a0months between rhBMP\u20102\/ACS and autogenous bone graft (3.2\u00a0\u00b1\u00a00.9\u00a0mm <jats:italic>versus<\/jats:italic> 3.7\u00a0\u00b1\u00a01.4\u00a0mm; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.31). Sixty\u2010two implants were placed after 6\u00a0month of healing with no significant differences between groups for number of implants, implant size, primary stability and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>rhBMP\u20102\/ACS appears a realistic alternative for augmentation of the edentulous atrophic anterior maxilla.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12148","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T12:14:39Z","timestamp":1374495279000},"page":"968-975","source":"Crossref","is-referenced-by-count":69,"title":["Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP\u20102\/ACS or autogenous bone grafts: a proof\u2010of\u2010concept randomized clinical trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Rubens Moreno","family":"de Freitas","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery \u2013 Periodontics UNESP \u2013 Univ Estadual Paulista, Araraquara Dental School Araraquara SP Brazil"},{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Departments of Periodontics and Oral Biology College of Dental Medicine Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Susin","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Departments of Periodontics and Oral Biology College of Dental Medicine Augusta GA USA"},{"name":"Department of Orthopedics, Medical College of Georgia Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens","family":"Spin\u2010Neto","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery \u2013 Periodontics UNESP \u2013 Univ Estadual Paulista, Araraquara Dental School Araraquara SP Brazil"},{"name":"Department of Dentistry Oral Radiology Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Marcantonio","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery \u2013 Periodontics UNESP \u2013 Univ Estadual Paulista, Araraquara Dental School Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf M. E.","family":"Wikesj\u00f6","sequence":"additional","affiliation":[{"name":"Laboratory for Applied Periodontal &amp; Craniofacial Regeneration Departments of Periodontics and Oral Biology College of Dental Medicine Augusta GA USA"},{"name":"Department of Orthopedics, Medical College of Georgia Georgia Regents University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Ant\u00f4nio Violin Dias","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology UNICAMP \u2013 State University of Campinas, Institute of Biology Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Elcio","family":"Marcantonio","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery \u2013 Periodontics UNESP \u2013 Univ Estadual Paulista, Araraquara Dental School Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,2]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.08.018"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.08.018"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.01.058"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.8.1241"},{"key":"e_1_2_14_6_1","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003878.pub4","article-title":"Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant treatment","volume":"7","author":"Esposito M.","year":"2009","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_14_7_1","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003878.pub4","article-title":"Interventions for replacing missing teeth: bone augmentation techniques for dental implant treatment","volume":"16","author":"Esposito M.","year":"2009","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.4.605"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.11.021"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.06.670"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.12.1186"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.00921.x"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01648.x"},{"key":"e_1_2_14_14_1","first-page":"61","article-title":"The negative effect of combining rhBMP\u20102 and Bio\u2010Oss on bone formation for maxillary sinus augmentation","volume":"32","author":"Kao D. 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