{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:09:03Z","timestamp":1771672143101,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine microbiological and immunological alterations following two periodontal surgical techniques, over a 6\u2010month period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 30 chronic periodontitis patients participated in the present randomized controlled clinical trial and were randomized in two groups. Modified Widman flap (MWF) was applied in the control group and apically positioned flap (APF), without intervention to the bone, in the experimental group. Gingival crevicular fluid samples and subgingival plaque samples from the operated sites were collected at baseline, 6th, 12th and 24th post\u2010operative week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No major differences were noticed in immunological and microbiological profile of patients receiving either modified MWF or APF, for a period of 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The choice of the periodontal surgical procedure does not seem to affect the immunological and the microbiological profile of patients with chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12149","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T15:22:39Z","timestamp":1375111359000},"page":"1036-1042","source":"Crossref","is-referenced-by-count":5,"title":["Immunological and microbiological findings after the application of two periodontal surgical techniques: a randomized, controlled clinical trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Thomas","family":"Kyriazis","sequence":"first","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology Dental School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Gkrizioti","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology Dental School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lazaros","family":"Tsalikis","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology Dental School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Sakellari","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology Dental School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristeides","family":"Deligianidis","sequence":"additional","affiliation":[{"name":"Immunology Department and Regional Tissue Typing Laboratory Hippocrates General Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonis","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology Dental School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,22]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1790","article-title":"Treatment of plaque\u2010induced gingivitis, chronic periodontitis and other clinical conditions","volume":"74","author":"American Academy of Periodontology","year":"2001","journal-title":"Journal of Periodontology"},{"key":"e_1_2_5_3_1","first-page":"405","article-title":"Guidelines for periodontal therapy","volume":"69","author":"American Academy of Periodontology (AAP)","year":"1998","journal-title":"Journal of Periodontology"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.5.478"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1964.35.1.5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1535"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.04.003"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00020.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00191.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00504.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290704.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-011-9754-x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01928.x"},{"key":"e_1_2_5_15_1","first-page":"555","article-title":"The short\u2010term effect of apically repositioned flap surgery on the composition of the subgingival microbiota","volume":"19","author":"Levy R. 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