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Samples were genotyped with the Affymetrix Genome\u2010Wide Human <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome\u2010based autosomal and X\u2010chromosomal genotypes and short insertions and deletions (<jats:styled-content style=\"fixed-case\">INDEL<\/jats:styled-content>s) was performed in both cohorts. Finally, more than 17 million <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s and short <jats:styled-content style=\"fixed-case\">INDEL<\/jats:styled-content>s were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No genome\u2010wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged &gt;60\u00a0years where excluded or not. Despite no single <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> association reached genome\u2010wide significance, the proportion of variance explained by additive effects of all common <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s was around 23% for mean proximal attachment loss. Excluding subjects aged &gt;60\u00a0years increased the explained variance to 34%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No single <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s were found to be genome\u2010wide significantly associated with chronic periodontitis in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12154","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T12:40:41Z","timestamp":1376484041000},"page":"977-985","source":"Crossref","is-referenced-by-count":139,"title":["Genome\u2010wide association study of chronic periodontitis in a general German population"],"prefix":"10.1111","volume":"40","author":[{"given":"Alexander","family":"Teumer","sequence":"first","affiliation":[{"name":"Department of Functional Genomics Interfaculty Institute for Genetics and Functional Genomics University Medicine Greifswald Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Holtfreter","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry, Periodontology and Endodontology University Medicine Greifswald Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"V\u00f6lker","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics Interfaculty Institute for Genetics and Functional Genomics University Medicine Greifswald Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Petersmann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Nauck","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Biffar","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, Gerostomatology and Dental Materials University Medicine Greifswald Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University Medicine Greifswald Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyo K.","family":"Kroemer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Center of Drug Absorption and Transport (CDAT) University Medicine Greifswald Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Meisel","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry, Periodontology and Endodontology University Medicine Greifswald Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Homuth","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics Interfaculty Institute for Genetics and Functional Genomics University Medicine Greifswald Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Greifswald 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