{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:54:23Z","timestamp":1791809663320,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,15]],"date-time":"2013-09-15T00:00:00Z","timestamp":1379203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The aim of this randomized placebo\u2010controlled clinical trial was to evaluate the effects of\n                      <jats:italic>Lactobacillus reuteri\u2010<\/jats:italic>\n                      containing probiotic lozenges as an adjunct to scaling and root planing (\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Thirty chronic periodontitis patients were recruited and monitored clinically and microbiologically at baseline, 3, 6, 9 and 12\u00a0weeks after therapy. All patients received one\u2010stage full\u2010mouth disinfection and randomly assigned over a test (\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      \u00a0+\u00a0probiotic,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015) or control (\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      \u00a0+\u00a0placebo,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015) group. The lozenges were used two times a day for 12\u00a0weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At week 12, all clinical parameters were significantly reduced in both groups, while there was significantly more pocket depth reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) and attachment gain (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) in moderate and deep pockets; more\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      reduction was observed in the\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      \u00a0+\u00a0probiotic group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The results indicate that oral administration of\n                      <jats:italic>L. reuteri<\/jats:italic>\n                      lozenges could be a useful adjunct to\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      in chronic periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12155","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T07:43:18Z","timestamp":1376466198000},"page":"1025-1035","source":"Crossref","is-referenced-by-count":284,"title":["Clinical and microbiological effects of\n                    <i>Lactobacillus reuteri<\/i>\n                    probiotics in the treatment of chronic periodontitis: a randomized placebo\u2010controlled study"],"prefix":"10.1111","volume":"40","author":[{"given":"Wim","family":"Teughels","sequence":"first","affiliation":[{"name":"Periodontology Section Department of Oral Sciences Faculty of Medicine Catholic University Leuven Leuven Belgium"},{"name":"Periodontology Section Dentistry University Hospitals Leuven Leuven Belgium"},{"name":"Fund for Scientific Research Flanders (FWO) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anda\u00e7","family":"Durukan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Cukurova University Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"Ozcelik","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Cukurova University Adana 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