{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:04:06Z","timestamp":1778619846482,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ETEP Research Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the efficacy of a 0.07% cetylpyridinium chloride (<jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>) mouth rinse in the control of plaque and gingival inflammation during a 6\u2010month period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Adult subjects with moderate gingivitis were selected [\u226540% bleeding on marginal probing (<jats:styled-content style=\"fixed-case\">BOMP<\/jats:styled-content>)]. After retrieving microbiological samples and evaluating the clinical parameters (plaque, BOMP and stain indexes), a professional prophylaxis was performed and subjects were randomly assigned to the test (<jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> mouth rinse) or to the placebo group. Subjects were re\u2010assessed after 3 and 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 67 patients (35 test, 32 placebo) were included in the analysis. At 6\u00a0months, intra\u2010group significant plaque reductions were observed in the test group (0.691, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), but not in the placebo (0.181, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.653). At 6\u00a0months, the mean <jats:styled-content style=\"fixed-case\">BOMP<\/jats:styled-content> values were lower in the test group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.052). Changes between baseline and 6\u00a0months were significantly higher in the test group both for <jats:styled-content style=\"fixed-case\">plaque<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and <jats:styled-content style=\"fixed-case\">BOMP<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.037) when compared with the placebo. A microbiological impact was observed in the test group, especially for <jats:italic>Prevotella intermedia<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The evaluated 0.07% <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>\u2010based mouth rinse, used three times per day adjunctively to mechanical tooth cleaning, prevents plaque accumulation and gingival inflammation, as compared to the placebo, for at least 6\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12158","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T11:43:33Z","timestamp":1376480613000},"page":"1007-1015","source":"Crossref","is-referenced-by-count":51,"title":["Efficacy of a new mouth rinse formulation based on 0.07% cetylpyridinium chloride in the control of plaque and gingivitis: a 6\u2010month randomized clinical trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Xavier","family":"Costa","sequence":"first","affiliation":[{"name":"Section of Graduate Periodontology \u2013 Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estefan\u00eda","family":"Laguna","sequence":"additional","affiliation":[{"name":"Section of Graduate Periodontology \u2013 Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Herrera","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal Diseases (ETEP) Research Group \u2013 Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Serrano","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal Diseases (ETEP) Research Group \u2013 Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Alonso","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal Diseases (ETEP) Research Group \u2013 Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal Diseases (ETEP) Research Group \u2013 Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01103.x"},{"key":"e_1_2_6_3_1","first-page":"20","article-title":"Efficacy of a mouthrinse containing 0.05% cetylpyridinium chloride for the control of plaque and gingivitis: a 6\u2010month clinical study in adults","volume":"19","author":"Allen D. 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