{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:38:24Z","timestamp":1762623504011},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute for Health and Welfare"},{"name":"Social Insurance Institution of Finland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The goal of this study was to explore whether insulin resistance and beta cell function are related to periodontal pocket formation, indicative of infectious periodontal disease in non\u2010smoking adults without manifest diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We analysed data from a Health 2000 Survey consisting of dentate subjects without any indication of diabetes, aged between 30 and 64, who had never smoked and who had participated in the Follow\u2010up Study on Finnish Adults' Oral Health about 4\u00a0years later (<jats:italic>n<\/jats:italic>\u00a0=\u00a0157). The Homeostasis Model Assessment Indices were used to measure insulin resistance (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) and \u03b2\u2010cell function (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010B). The development of periodontal disease was measured by means of the incidence of deepened periodontal pockets (4\u00a0mm deep or deeper) during the follow\u2010up period. Incidence rate ratios (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>) were estimated using Poisson regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010B indices were associated with periodontal pocket formation during the 4\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this follow\u2010up study suggest that impaired glucose metabolism measured as insulin resistance and altered beta cell function predict the breakdown of periodontal tissues. Further studies about their role in the pathogenesis of periodontal diseases are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12162","type":"journal-article","created":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T11:19:34Z","timestamp":1378811974000},"page":"1079-1086","source":"Crossref","is-referenced-by-count":25,"title":["Role of insulin sensitivity and beta cell function in the development of periodontal disease in adults without diabetes"],"prefix":"10.1111","volume":"40","author":[{"given":"Petra","family":"Timonen","sequence":"first","affiliation":[{"name":"Department of Periodontology and Geriatric Dentistry Institute of Dentistry University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomas","family":"Saxlin","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Geriatric Dentistry Institute of Dentistry University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Knuuttila","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Geriatric Dentistry Institute of Dentistry University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Liisa","family":"Suominen","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare (THL) Kuopio Finland"},{"name":"Institute of Dentistry University of Eastern Finland Kuopio Finland"},{"name":"Oral and Maxillofacial Department Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Jula","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare (THL) Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tellervo","family":"Tervonen","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Geriatric Dentistry Institute of Dentistry University of Oulu Oulu Finland"},{"name":"Department of Oral and Maxillofacial Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Yl\u00f6stalo","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Geriatric Dentistry Institute of Dentistry University of Oulu Oulu Finland"},{"name":"Institute of Dentistry University of Eastern Finland Kuopio Finland"},{"name":"Oral and Maxillofacial Department Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Health and Functional Capacity in Finland. 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