{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:28:05Z","timestamp":1780486085690,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81271106"],"award-info":[{"award-number":["81271106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81321002"],"award-info":[{"award-number":["81321002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p><jats:italic>Matrix metalloproteinase\u20101<\/jats:italic> promoter \u20101607 1G\/2G (rs1799750) polymorphism have been shown to confer genetic susceptibility to chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>), but the results are inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A meta\u2010analysis and systematic review was performed to accomplish a more precise estimation of the relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pooled estimates revealed that there was no significant association between this polymorphism and <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> risk in Caucasian and Asian populations. In addition, it was reported by three Brazilian studies that no significant association was found for this polymorphism with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> risk in a Brazilian mixed population. Besides, there was no significant association of this polymorphism with mild to moderate and severe <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> risk in both Caucasian and Asian populations. Moreover, both non\u2010smokers and smokers did not have a significant association between this polymorphism and susceptibility to <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> in Caucasian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Matrix metalloproteinase\u20101<\/jats:italic> promoter \u22121607 1G\/2G (rs1799750) polymorphism may have no effect on the disease susceptibility of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> in Caucasian, Asian and Brazilian mixed populations. Besides, this polymorphism may not play a direct role in severity of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> among both Caucasian and Asian populations, and between this polymorphism and smoking there may be no interactions to be associated with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> risk in Caucasian population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12166","type":"journal-article","created":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T11:32:26Z","timestamp":1378812746000},"page":"1095-1103","source":"Crossref","is-referenced-by-count":8,"title":["Matrix metalloproteinase\u20101 promoter \u20101607 1G\/2G polymorphism and chronic periodontitis susceptibility: a meta\u2010analysis and systematic review"],"prefix":"10.1111","volume":"40","author":[{"given":"Wenyang","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Central Hospital of Fuling Fuling Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00979.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg285"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(95)80116-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00806.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2006.00615.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00148.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00547.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb01814.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00553.x"},{"key":"e_1_2_5_12_1","first-page":"4225","article-title":"Correlation between expression of the matrix metalloproteinase\u20101 gene in ovarian cancers and an insertion\/deletion polymorphism in its promoter region","volume":"59","author":"Kanamori Y.","year":"1999","journal-title":"Cancer Research"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240110.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.03.011"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.01.013"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12128"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.821"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0557"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01302.x"},{"key":"e_1_2_5_22_1","first-page":"121","article-title":"An association between the matrix metalloproteinase 1 promoter gene polymorphism and lymphnode metastasis in breast cancer","volume":"23","author":"Przybylowska K.","year":"2004","journal-title":"Journal of Experimental & Clinical Cancer Research : CR"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01447.x"},{"key":"e_1_2_5_24_1","first-page":"5321","article-title":"A single nucleotide polymorphism in the matrix metalloproteinase\u20101 promoter creates an Ets binding site and augments transcription","volume":"58","author":"Rutter J. L.","year":"1998","journal-title":"Cancer Research"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600800103"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.300202.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01313.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v6.i4.40"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070112.80711.3D"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.060037197"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:43:44Z","timestamp":1696178624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,17]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/jcpe.12166"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12166","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,17]]}}}