{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:07:53Z","timestamp":1783512473973,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T00:00:00Z","timestamp":1382918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science, and Technology","doi-asserted-by":"crossref","award":["2011-0007795"],"award-info":[{"award-number":["2011-0007795"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The objective of this study was to determine the efficacy of bone morphogenetic protein 2 (<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102) in a bovine hydroxyapatite\/collagen (<jats:styled-content style=\"fixed-case\">BHC<\/jats:styled-content>) carrier to augment bone formation in a canine nasal sinus model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight mongrel dogs, approximately 12\u00a0months old and 30\u00a0kg in weight were used. Following preparation of bilateral sinus access windows, BHC alone (control) or loaded with <jats:italic>E. coli<\/jats:italic>\u2010derived BMP\u20102 at 0.1\u00a0mg\/ml was implanted in four animals, and BHC loaded with <jats:italic>E. coli<\/jats:italic>\u2010derived BMP\u20102 at 0.5 and 1.5\u00a0mg\/ml was implanted in four animals. The animals were euthanized at 20\u00a0weeks when block sections were obtained for micro\u2010computed tomography and histometric analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total augmented volumes did not differ significantly between groups. Histometric analysis showed significantly enhanced bone formation for the <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 groups compared with control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BMP\u20102 in a BHC carrier, even at the low 0.1\u2010mg\/ml concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12174","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:56:54Z","timestamp":1381543014000},"page":"86-93","source":"Crossref","is-referenced-by-count":40,"title":["Sinus augmentation using <scp>BMP<\/scp>\u20102 in a bovine hydroxyapatite\/collagen carrier in dogs"],"prefix":"10.1111","volume":"41","author":[{"given":"Jae\u2010Kook","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul 120\u2010752 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul 120\u2010752 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul 120\u2010752 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul 120\u2010752 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoo\u2010Sung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul 120\u2010752 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ui\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul 120\u2010752 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.2.5751"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10543400701329497"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.08.018"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2012.0724"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02222.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.02.010"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1998.090207.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2001.tb00236.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00251.x"},{"key":"e_1_2_5_11_1","first-page":"785","article-title":"Bone formation and osseointegration stimulated by rhBMP\u20102 following subantral augmentation procedures in nonhuman primates","volume":"12","author":"Hanisch O.","year":"1997","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650101110"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.03.010"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.075"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02419.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532051"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01939.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.02110.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01343.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181b09bef"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01477.x"},{"key":"e_1_2_5_22_1","first-page":"201","article-title":"BIO\u2010OSS\u2013a resorbable bone substitute?","volume":"8","author":"Schlegel A. 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