{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:14:28Z","timestamp":1790486068701,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the levels of a wide panel of cyto\/chemokines in the gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) of uncontrolled type 2 diabetic subjects as compared with non\u2010diabetic subjects with periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six uncontrolled type 2 diabetic subjects (glycated haemoglobin levels &gt;7.5%) and 20 non\u2010diabetic subjects with chronic periodontitis were enrolled in this study. The levels of 14 cyto\/chemokines were measured in the <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> of healthy and diseased sites of the diabetic and non\u2010diabetic subjects using multiplex bead immunoassays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentrations of eotaxin, macrophage inflammatory protein\u20101\u03b1, granulocyte\u2010macrophage colony\u2010stimulating factor, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20106, tumour necrosis factor\u2010\u03b1 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012 were higher in healthy and diseased sites of diabetic than non\u2010diabetic subjects, after adjustment for multiple comparisons (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Uncontrolled type 2 diabetes mellitus modulated the local levels of several cyto\/chemokines at both healthy and diseased periodontal sites in favour of a proinflammatory profile, which may partially explain the greater susceptibility of diabetic subjects to periodontal breakdown.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12179","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T06:36:45Z","timestamp":1384151805000},"page":"11-18","source":"Crossref","is-referenced-by-count":69,"title":["Local levels of inflammatory mediators in uncontrolled type 2 diabetic subjects with chronic periodontitis"],"prefix":"10.1111","volume":"41","author":[{"given":"Poliana M.","family":"Duarte","sequence":"first","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce P.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamires S.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Feres","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Chambrone","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana M.","family":"Shaddox","sequence":"additional","affiliation":[{"name":"Department of Periodontology University of Florida College of Dentistry Gainesville Florida USA"},{"name":"Department of Oral Biology University of Florida College of Dentistry Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2011.09.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.43.171"},{"key":"e_1_2_6_6_1","first-page":"695","article-title":"Pro\u2010 versus anti\u2010inflammatory cytokines: myth or reality","volume":"47","author":"Cavaillon J. 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