{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:01:58Z","timestamp":1790550118542,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008364","name":"Danish Dental Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008364","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Danish Foundation"},{"name":"Health Insurance Foundation"},{"DOI":"10.13039\/501100014553","name":"Simon Spies Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014553","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Periodontitis is a multifactorial disease in which subgingival bacteria play an important role in the pathogenesis of the disease. The objective of this study was to determine if periodontitis is associated with a characteristic salivary bacterial profile. This was accomplished by comparing the bacterial profile of saliva from subjects with chronic periodontitis with that of saliva from a control cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Stimulated saliva samples from 139 chronic periodontitis patients and 447 samples from a control cohort were analysed using the Human Oral Microbe Identification Microarray (<jats:styled-content style=\"fixed-case\">HOMIM<\/jats:styled-content>). Frequency and levels (mean <jats:styled-content style=\"fixed-case\">HOMIM<\/jats:styled-content>\u2010value) of around 300 bacterial taxa\/clusters in samples were used as parameters for investigation. Differences at taxon\/cluster values between groups were analysed using Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test with Benjamini\u2013Hochberg correction for multiple comparisons. Principal component analysis was used to visualize bacterial community profiles obtained by the <jats:styled-content style=\"fixed-case\">HOMIM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight bacterial taxa, including putative periodontal pathogens as <jats:italic>Parvimonas micra<\/jats:italic> and <jats:italic>Filifactor alocis<\/jats:italic>, and four bacterial clusters were identified statistically more frequently and at higher levels in samples from periodontitis patients than in samples from the control cohort. These differences were independent of the individuals' smoking status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontitis is associated with a characteristic bacterial profile of saliva different from that of a control cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12190","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T16:35:53Z","timestamp":1383755753000},"page":"104-112","source":"Crossref","is-referenced-by-count":99,"title":["Differences in bacterial saliva profile between periodontitis patients and a control cohort"],"prefix":"10.1111","volume":"41","author":[{"given":"Daniel","family":"Belstr\u00f8m","sequence":"first","affiliation":[{"name":"Section of Periodontology School of Dentistry Faculty of Health Science University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils\u2010Erik","family":"Fiehn","sequence":"additional","affiliation":[{"name":"Department of International Health Immunology &amp; Microbiology University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus H.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Rheumatology Institute for Inflammation Research Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Kirkby","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svante","family":"Twetman","sequence":"additional","affiliation":[{"name":"Section of Cariology School of Dentistry Faculty of Health Science University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanja","family":"Klepac\u2010Ceraj","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Wellesley College Wellesley MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Paster","sequence":"additional","affiliation":[{"name":"Department of Microbiology The Forsyth Institute Cambridge MA USA"},{"name":"Department of Oral Medicine Infection &amp; Immunity Harvard School of Dental Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle","family":"Holmstrup","sequence":"additional","affiliation":[{"name":"Section of Periodontology School of Dentistry Faculty of Health Science University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00350.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jebdp.2005.12.018"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110566"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090185"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00542-10"},{"key":"e_1_2_6_7_1","first-page":"560","article-title":"Predominant cultivable micro\u2010organisms inhabiting periodontal pockets","volume":"124","author":"Dwyer D. 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