{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:08:21Z","timestamp":1787015301883,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare immediate surgery to scaling and root planing (SRP) in the treatment of advanced periodontal disease focusing on the prevalence of residual sites and cost\u2010effectiveness (1); to evaluate the adjunctive effects of azithromycin in a second treatment phase (2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010nine patients (18 males, 21 females; mean age: 54.6) received oral hygiene instructions and were randomly allocated to surgery (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a019) or SRP (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020). Patients with residual pockets (\u22656\u00a0mm) at 6\u00a0months received re\u2010debridement of these sites and systemic azithromycin. Treatment groups were followed up to 12\u00a0months and evaluated in terms of clinical response parameters and cost\u2010effectiveness. Chair\u2010time was used to assess the financial impact of treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both treatment arms were equally effective in terms of clinical outcome demonstrating less than 1% residual pockets at 12\u00a0months. Surgery imposed an extra 746 Euro on the patient up to 6\u00a0months when compared to SRP. At 12\u00a0months, 46 Euro of this amount could be offset as a result of a reduced need for supportive care. Only 6 patients in the surgery group needed systemic antibiotics, whereas 14 patients in the SRP needed such additional treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although 700 Euro could be saved on average by performing SRP instead of surgery, the latter significantly reduced the need for supportive care and systemic antibiotics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12201","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T07:35:04Z","timestamp":1385019304000},"page":"164-171","source":"Crossref","is-referenced-by-count":15,"title":["A randomized controlled trial on immediate surgery\n                    <i>versus<\/i>\n                    root planing in patients with advanced periodontal disease: a cost\u2010effectiveness analysis"],"prefix":"10.1111","volume":"41","author":[{"given":"Seyed Reza","family":"Miremadi","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Implantology Dental School Faculty of Medicine and Health Sciences University of Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"De Bruyn","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology Dental School Faculty of Medicine and Health Sciences University of Ghent Ghent Belgium"},{"name":"Department of Prosthodontics Faculty of Odontology Malm\u00f6 University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Steyaert","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology Dental School Faculty of Medicine and Health Sciences University of Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrijn","family":"Princen","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology Dental School Faculty of Medicine and Health Sciences University of Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran M.","family":"Sabzevar","sequence":"additional","affiliation":[{"name":"Dental Medicine Faculty of Medicine and Pharmacy Free University of Brussels (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Cosyn","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology Dental School Faculty of Medicine and Health Sciences University of Ghent Ghent Belgium"},{"name":"Dental Medicine Faculty of Medicine and Pharmacy Free University of Brussels (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660110501"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02039.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb00839.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1600-051X.1990.tb01070.x","article-title":"Scores of plaque, bleeding, suppuration and probing depth to predict probing attachment loss. 5\u00a0years of observation following nonsurgical periodontal therapy","volume":"17","author":"Badersten A.","year":"1990","journal-title":"Journal of Clinical 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