{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:14:16Z","timestamp":1789528456541,"version":"build-2803163510"},"reference-count":84,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Health","award":["P20GM103538"],"award-info":[{"award-number":["P20GM103538"]}]},{"name":"National Institute of Health","award":["UL1TR000117"],"award-info":[{"award-number":["UL1TR000117"]}]},{"name":"Caribbean Primate Research Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Gingival tissues of periodontitis lesions contribute to local elevations in mediators, including both specific T cell and antibody immune responses to oral bacterial antigens. Thus, antigen processing and presentation activities must exist in these tissues to link antigen\u2010presenting cells with adaptive immunity. We hypothesized that alterations in the transcriptome of antigen processing and presentation genes occur in ageing gingival tissues and that periodontitis enhances these differences reflecting tissues less capable of immune resistance to oral pathogens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Rhesus monkeys (<jats:italic>n<\/jats:italic>\u00a0=\u00a034) from 3 to 23\u00a0years of age were examined. A buccal gingival sample from healthy or periodontitis sites was obtained, total <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> isolated, and microarray analysis was used to describe the transcriptome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results demonstrated increased transcription of genes related to the <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and negative regulation of <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells with ageing in healthy gingival tissues. In contrast, both adult and ageing periodontitis tissues showed decreased transcription of genes for <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> antigens, coincident with up\u2010regulation of <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> class I\u2010associated genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These transcriptional changes suggest a response of healthy ageing tissues through the class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> pathway (<jats:italic>i.e<\/jats:italic>. endocytosed antigens) and altered responses in periodontitis that could reflect host\u2010associated self\u2010antigens or targeting cytosolic intracellular microbial pathogens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12212","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T15:51:01Z","timestamp":1386172261000},"page":"327-339","source":"Crossref","is-referenced-by-count":44,"title":["Comparative analysis of gingival tissue antigen presentation pathways in ageing and periodontitis"],"prefix":"10.1111","volume":"41","author":[{"given":"Octavio A.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Novak","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenatha","family":"Kirakodu","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Orraca","sequence":"additional","affiliation":[{"name":"School of Dental Medicine University of Puerto Rico San Juan PR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuey\u2010Chu","family":"Chen","sequence":"additional","affiliation":[{"name":"Microarray Core Facility College of Medicine University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arny","family":"Stromberg","sequence":"additional","affiliation":[{"name":"Department of Statistics College of Arts &amp; Sciences University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis","family":"Gonzalez\u2010Martinez","sequence":"additional","affiliation":[{"name":"Caribbean Primate Research Center University of Puerto Rico San Juan PR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Ebersole","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research College of Dentistry University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00353.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-009-0374-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.1.403"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.11.4034-4041.1991"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2011.00863.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2855"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.05.015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152807780832274"},{"key":"e_1_2_6_10_1","first-page":"46","article-title":"Have we become so focused on inflammation and host response that we have neglected the role of bacteria in initiating periodontal disease?","volume":"30","author":"Cobb C. M.","year":"2009","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.057125"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02918178"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500801"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046440"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028003233.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03006-05"},{"key":"e_1_2_6_17_1","first-page":"229","article-title":"The bacteriology of sheep periodontitis with special reference to Actinbacillus actinomycetemcomitans","volume":"41","author":"Dreyer W. P.","year":"1986","journal-title":"The Journal of the Dental Association of South Africa"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-26363-2_7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2003.03109.x"},{"key":"e_1_2_6_20_1","first-page":"111","volume-title":"Fundamentals of Periodontics","author":"Ebersole J. L.","year":"2003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302x.2000.150104.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2002.7.1.102"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1999.tb02266.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790060301"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080464"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00258-07"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04202.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01051.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-010-9501-7"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2010.08.004"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.08.011"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.11.013"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511403744"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329675"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324904"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2009.00562.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2004.12.018"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3684"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04314.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2012.04.001"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3336774"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2009.00082.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.15.5616-5625.2002"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01701.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/298348"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02790403"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4693"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060180"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00169.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2010.00646.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2007.10.003"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(94)35135-X"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb01782.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2010.10.008"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2009.00555.x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-3274(02)00062-X"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.6.686"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080645"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/754857"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-221"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0266"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.78"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00800.x"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb02096.x"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1994.tb00043.x"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.12.016"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2004.31.10.570"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080480"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01436.x"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.1166-1168.2004"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.6.497"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.565437"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.11.005"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512456551"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601004010037"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2006.00296.x"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.01.001"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0109005"},{"key":"e_1_2_6_79_1","first-page":"1","article-title":"Heat shock protein magic in antigen trafficking within dendritic cells: implications in antigen cross\u2010presentation in immunity","volume":"66","author":"Udono H.","year":"2012","journal-title":"Acta Medica Okayama"},{"key":"e_1_2_6_80_1","first-page":"3","article-title":"Risk factors for periodontitis","volume":"7","author":"Dyke T. E.","year":"2005","journal-title":"Journal of the International Academy of Periodontology"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050376"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v2i0.5070"},{"key":"e_1_2_6_83_1","first-page":"279","article-title":"The relationship between periodontal disease and osteoporosis in animals","volume":"16","author":"Yoshinari N.","year":"2006","journal-title":"Clinical Calcium"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2006.00585.x"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1080\/08830180902978120"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T06:01:32Z","timestamp":1731909692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,7]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/jcpe.12212"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12212","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,7]]}}}