{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:53:07Z","timestamp":1768913587676,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry Health"},{"name":"Tuscan Region","award":["GR-2009-1592229"],"award-info":[{"award-number":["GR-2009-1592229"]}]},{"DOI":"10.13039\/501100007514","name":"University of Pisa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the effectiveness of enamel matrix derivative (<jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>) in the treatment of periodontal pockets of suprabony defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomized Clinical Trials comparing open flap debridement <jats:styled-content style=\"fixed-case\">(OFD) <\/jats:styled-content><jats:italic>versus <\/jats:italic><jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> in periodontal suprabony defects were identified through electronic and manual search. Screening, data extraction and quality assessment were conducted. The primary outcome measures were tooth survival (TS) and clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) gain. Pocket probing depth (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) reduction and recession (<jats:styled-content style=\"fixed-case\">REC<\/jats:styled-content>) increase were secondary outcome measures. Information concerning clinical and radiological bone gain was also collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search identified 1170 studies, three articles reporting on (99 subjects\/358 teeth) met the inclusion criteria and were included. No tooth was lost during follow\u2010up (8\u201312\u00a0months). The adjunctive mean benefit of <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> was: 1.2\u00a0mm for <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> gain [confidence interval (CI): (0.9, 1.4), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00001, I<jats:sup>2<\/jats:sup>\u00a0=\u00a066%], 1.2\u00a0mm for the <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> reduction (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: [0.8, 1.5], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001, I<jats:sup>2<\/jats:sup>\u00a0=\u00a00%), \u22120.5\u00a0mm for the <jats:styled-content style=\"fixed-case\">REC<\/jats:styled-content> increase (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: [\u22120.8, \u22120.2], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003, I<jats:sup>2<\/jats:sup>\u00a0=\u00a00%). Potential risk of bias was identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No differences were noted in TS but <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> application resulted in clinical and radiographic additional benefits compared to <jats:styled-content style=\"fixed-case\">OFD<\/jats:styled-content> alone. Nevertheless, the paucity of data, the risk of methodological and potential publication bias suggests caution in interpreting these results while supporting multicenter studies for this specific application.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12218","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T12:34:04Z","timestamp":1386938044000},"page":"377-386","source":"Crossref","is-referenced-by-count":32,"title":["Does enamel matrix derivative application provide additional clinical benefits in residual periodontal pockets associated with suprabony defects? A systematic review and meta\u2010analysis of randomized clinical trials"],"prefix":"10.1111","volume":"41","author":[{"given":"Filippo","family":"Graziani","sequence":"first","affiliation":[{"name":"Department of Surgical Medicine Molecular Pathology and Critical Area University of Pisa Pisa Italy"},{"name":"University Hospital of Pisa Sub\u2010Unit of Periodontology and Periodontal Medicine Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Gennai","sequence":"additional","affiliation":[{"name":"Department of Surgical Medicine Molecular Pathology and Critical Area University of Pisa Pisa Italy"},{"name":"University Hospital of Pisa Sub\u2010Unit of Periodontology and Periodontal Medicine Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Cei","sequence":"additional","affiliation":[{"name":"Department of Surgical Medicine Molecular Pathology and Critical Area University of Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ducci","sequence":"additional","affiliation":[{"name":"Department of Surgical Medicine Molecular Pathology and Critical Area University of Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Discepoli","sequence":"additional","affiliation":[{"name":"University Hospital of Pisa Sub\u2010Unit of Periodontology and Periodontal Medicine Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Carmignani","sequence":"additional","affiliation":[{"name":"Department of Surgical Medicine Molecular Pathology and Critical Area University of Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Tonetti","sequence":"additional","affiliation":[{"name":"European Research Group on Periodontology Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-002-0185-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01264.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0810776"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01202.x"},{"key":"e_1_2_5_6_1","first-page":"589","article-title":"The simplified papilla preservation flap. 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