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Little is known about this association in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the extent to which plasma undercarboxylated osteocalcin (uc<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>) is associated with gingival crevicular fluid tumour necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">GCF TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>) \u2013 a potential marker of gingival inflammation \u2013 in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from the <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uebec Adipose and Lifestyle InvesTigation in Youth cohort, an ongoing longitudinal study on the natural history of obesity among Caucasian children with a family history of obesity in Quebec, Canada. This cross\u2010sectional analysis from the baseline visit includes 120 children aged 8\u201310\u00a0years. Plasma uc<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GCF TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> levels were determined by enzyme\u2010linked immunosorbent assay. Linear regression analyses, adjusting for age, gender, family income, sexual maturity stage, daily physical activity, obesity, and fasting glucose were conducted, with <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> level as the dependent variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 1\u2010ng\/ml increase in uc<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content> was associated with a 0.96% decrease (95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): \u22121.69, \u22120.23) in <jats:styled-content style=\"fixed-case\">GCF TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A negative association between a marker of bone formation and a marker of gingival inflammation was observed as early as childhood among Caucasian children with a family history of obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12232","type":"journal-article","created":{"date-parts":[[2014,1,26]],"date-time":"2014-01-26T08:14:46Z","timestamp":1390724086000},"page":"467-472","source":"Crossref","is-referenced-by-count":3,"title":["Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor\u2010<i>\u03b1<\/i> in children"],"prefix":"10.1111","volume":"41","author":[{"given":"Khady","family":"K\u00e2","sequence":"first","affiliation":[{"name":"Faculty of Dentistry McGill University Montreal QC Canada"},{"name":"Epidemiology and Biostatistics Unit INRS\u2010Armand\u2010Frappier Institute Laval QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Claude","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry McGill University Montreal QC Canada"},{"name":"Epidemiology and Biostatistics Unit INRS\u2010Armand\u2010Frappier Institute Laval QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon D.","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari T.","family":"Kaartinen","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry McGill University Montreal QC Canada"},{"name":"Faculty of Medicine Department of Medicine Division of Experimental Medicine McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vamsee D.","family":"Myneni","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"Henderson","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Pediatrics Centre Hospitalier Universitaire Sainte\u2010Justine and Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.4.644"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870115)59:2<329::AID-CNCR2820590227>3.0.CO;2-S"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700403"},{"key":"e_1_2_7_5_1","first-page":"107","article-title":"The relationship between diabetes mellitus and destructive periodontal disease: a meta\u2010analysis","volume":"7","author":"Chavarry N. 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