{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:12:34Z","timestamp":1789711954097,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","award":["1266053"],"award-info":[{"award-number":["1266053"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005634","name":"Finnish Dental Society Apollonia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sigrid Juselius Foundation"},{"DOI":"10.13039\/501100007417","name":"Paulo Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010133","name":"Aarne Koskelo Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010133","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Finnish Medical Society's Swedish Funds"},{"name":"Helsinki University Central Hospital Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Chronic periodontitis has an episodic and multifactorial character, with fluctuations in bacterial burden, inflammatory response, and tissue destruction. We investigated the association of selected salivary biomarkers with periodontal parameters and validated the use of a novel salivary diagnostic approach, the cumulative risk score (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>), in detection of periodontitis in subjects with angiographically verified coronary artery disease diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The concentrations of matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u20108, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20101<jats:italic>\u03b2<\/jats:italic>, and <jats:italic>Porphyromonas gingivalis<\/jats:italic> were analysed from saliva of 493 subjects. The subjects participated in a detailed clinical and radiographic oral examination. The <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> index, combining the three salivary biomarkers, was calculated for each subject.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High salivary concentrations of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic>, and <jats:italic>P. gingivalis<\/jats:italic> were associated with deepened periodontal pockets and alveolar bone loss, and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic> with bleeding on probing. The <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> index had a stronger association with moderate to severe periodontitis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.13; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.11\u201312.09) than any of the markers alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Salivary concentrations of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic>, and <jats:italic>P. gingivalis<\/jats:italic> are associated with various clinical and radiographic measures of periodontitis. The <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> index, combining the three salivary biomarkers, is associated with periodontitis more strongly than any of the markers alone regardless of the coronary artery disease status of the patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12234","type":"journal-article","created":{"date-parts":[[2014,1,26]],"date-time":"2014-01-26T08:14:56Z","timestamp":1390724096000},"page":"442-450","source":"Crossref","is-referenced-by-count":132,"title":["Salivary biomarkers of bacterial burden, inflammatory response, and tissue destruction in periodontitis"],"prefix":"10.1111","volume":"41","author":[{"given":"Aino","family":"Salminen","sequence":"first","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"},{"name":"Department of Oral and Maxillofacial Diseases Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulvi K.","family":"Gursoy","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Paju","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kati","family":"Hyv\u00e4rinen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"M\u00e4ntyl\u00e4","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e5re","family":"Buhlin","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"},{"name":"Division of Periodontology Department of Dental Medicine Karolinska Institutet Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"K\u00f6n\u00f6nen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku S.","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Department of Medicine Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"},{"name":"Department of Oral and Maxillofacial Diseases Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Sinisalo","sequence":"additional","affiliation":[{"name":"Department of Medicine Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirkko J.","family":"Pussinen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01775.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.035"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090510"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2337"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00900.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00288.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.01.013"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12020"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01563.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/621484"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01480.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1128\/iai.55.9.2148-2154.1987","article-title":"Bacterial antigens induce collagenase and prostaglandin E2 synthesis in human gingival fibroblasts through a primary effect on circulating mononuclear cells","volume":"55","author":"Heath J. 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