{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:21:03Z","timestamp":1762521663223},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T00:00:00Z","timestamp":1396828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MEXT KAKENHI","award":["24390470"],"award-info":[{"award-number":["24390470"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to elucidate whether the association between beta\u20103 adrenergic receptor polymorphism and periodontal disease is modified by body weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We enrolled 332 postmenopausal women and determined their HbA1C levels (%) and beta\u20103 adrenergic receptor (rs4994) genotypes. Periodontal parameters including clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) were measured. After selecting subjects for each body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) level, the prevalence rate ratio (<jats:styled-content style=\"fixed-case\">PRR<\/jats:styled-content>) by multiple Poisson regression analysis was calculated to evaluate the relationship between periodontal disease and beta\u20103 adrenergic receptor polymorphism. The number of sites with <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>\u22656\u00a0mm was used as a dependent variable, and beta\u20103 adrenergic receptor genotype [categorized as Arg non\u2010carriers (reference) or Arg carriers], age (y) and HbA1C (%) were adopted as independent variables. We converted the number of probing sites (<jats:italic>n<\/jats:italic>) to an offset variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">PRR<\/jats:styled-content> of the beta\u20103 adrenergic receptor genotype for the number of sites of <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>\u22656\u00a0mm showed a positive association in subjects with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u226525.0 and increased markedly with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">PRR<\/jats:styled-content> in subjects with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u226530 was 3.10 (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicates a positive association between periodontal disease and the beta\u20103 adrenergic receptor genotype in obese individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12235","type":"journal-article","created":{"date-parts":[[2014,1,26]],"date-time":"2014-01-26T08:15:01Z","timestamp":1390724101000},"page":"460-466","source":"Crossref","is-referenced-by-count":7,"title":["The interaction between beta\u20103 adrenergic receptor polymorphism and obesity to periodontal disease in community\u2010dwelling elderly Japanese"],"prefix":"10.1111","volume":"41","author":[{"given":"Akihiro","family":"Yoshihara","sequence":"first","affiliation":[{"name":"Department of Oral Health and Welfare Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Biological Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Oral Health Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Oral Health Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Community Preventive Medicine Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802609"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1993.tb01098.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15279.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01942.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491212700505"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300295-JLR200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810780"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510377793"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117914"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00194.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2075"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0578-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.2.461S"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-012-0613-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.29.951"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509350037"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000144047"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2001.00025.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.519652"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/609485"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.5.293"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.11.1699"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400904"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.046"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.9.1579"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2004.tb00291.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808133390717"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800031301"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1158-9"},{"key":"e_1_2_6_31_1","first-page":"415","article-title":"The importance of brown adipose tissue","volume":"23","author":"Timmons J. 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