{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:55:44Z","timestamp":1791888944986,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["471305\/2009-0"],"award-info":[{"award-number":["471305\/2009-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The regulation of Wnt\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010catenin signalling, which is crucial for osteoblast differentiation and for bone resorption, is driven by critical inhibitors such as sclerostin (\n                      <jats:styled-content style=\"fixed-case\">SOST<\/jats:styled-content>\n                      ) and dickkopf\u2010related protein 1 (\n                      <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\n                      1). As such, the aim of this study was to evaluate the involvement of\n                      <jats:styled-content style=\"fixed-case\">SOST<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\n                      1 in human chronic periodontitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Gingival biopsies and serum were sampled from systemically healthy non\u2010periodontitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015) and chronic periodontitis subjects (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015). The\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      and protein levels of SOST, DKK1 and TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      in periodontal tissues were measured by\n                      <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>\n                      and by enzyme\u2010linked immunosorbent assay (ELISA) respectively. Serum levels of SOST, DKK1 and TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      were assessed by ELISA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                      and protein levels of SOST, DKK1 and TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      were significantly increased in the gingival tissues of the chronic periodontitis when compared to the non\u2010periodontitis group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). In addition, circulating levels of SOST and TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , but not DKK1, were higher in the periodontitis group than in the non\u2010periodontitis group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">SOST<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>\n                      1 were upregulated in the periodontal tissues of chronic periodontitis subjects, suggesting a possible role of these molecules on periodontal tissues.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12245","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T01:58:38Z","timestamp":1393552718000},"page":"550-557","source":"Crossref","is-referenced-by-count":72,"title":["Involvement of the Wnt\u2010\n                    <i>\u03b2<\/i>\n                    \u2010catenin signalling antagonists, sclerostin and dickkopf\u2010related protein 1, in chronic periodontitis"],"prefix":"10.1111","volume":"41","author":[{"given":"Marcelo Henrique","family":"Napimoga","sequence":"first","affiliation":[{"name":"Laboratory of Immunology and Molecular Biology S\u00e3o Leopoldo Mandic Institute and Research Center Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Nametala","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Molecular Biology S\u00e3o Leopoldo Mandic Institute and Research Center Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Luiz","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Molecular Biology S\u00e3o Leopoldo Mandic Institute and Research Center Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamires Szeremeske","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeruza P.","family":"Bossonaro","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology S\u00e3o Leopoldo Mandic Institute and Research Center Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Dias","family":"Demasi","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology S\u00e3o Leopoldo Mandic Institute and Research Center Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poliana Mendes","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1736"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.479"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12066"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3074"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01810.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00615.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1538"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110324"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01500.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2186"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1901"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.02.017"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.015"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.3.391"},{"key":"e_1_2_6_18_1","first-page":"3","article-title":"Review of osteoimmunology and the host response in endodontic and periodontal lesions","volume":"17","author":"Graves D. 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