{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:59:18Z","timestamp":1790395158502,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,6]],"date-time":"2014-04-06T00:00:00Z","timestamp":1396742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81271158"],"award-info":[{"award-number":["81271158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81000449"],"award-info":[{"award-number":["81000449"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Science and Technology Program Fund","award":["Z101107050210031"],"award-info":[{"award-number":["Z101107050210031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the direct effects of periodontal therapy in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hronic <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>bstructive <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ulmonary <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease (<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>) patients with chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In a pilot randomized controlled trial, 60 <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> were randomly assigned to receive scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) treatment, supragingival scaling treatment, or oral hygiene instructions only with no periodontal treatment. We evaluated their periodontal indexes, respiratory function, and <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> exacerbations at baseline, 6\u00a0months, 1, and 2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control group, measurements of periodontal indexes were significantly improved in patients in two treatment groups at 6\u2010month, 1\u2010year, and 2\u2010year follow\u2010up (all <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Overall, the means of forced expiratory volume in the first second\/forced vital capacity (<jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">FVC<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">FEV<\/jats:styled-content>1 were significantly higher in the two therapy groups compared with the control group during the follow\u2010up (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). In addition, the frequencies of <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> exacerbation were significantly lower in the two therapy groups than in the control group at 2\u2010year follow\u2010up (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our preliminary results from this pilot trial suggest that periodontal therapy in <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> may improve lung function and decrease the frequency of <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content> exacerbation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12247","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T19:18:50Z","timestamp":1393960730000},"page":"564-572","source":"Crossref","is-referenced-by-count":113,"title":["Effects of periodontal treatment on lung function and exacerbation frequency in patients with chronic obstructive pulmonary disease and chronic periodontitis: A 2\u2010year pilot randomized controlled trial"],"prefix":"10.1111","volume":"41","author":[{"given":"Xuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Stomatology Beijing ChaoYang Hospital affiliated to Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Stomatology Beijing ChaoYang Hospital affiliated to Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Beijing ChaoYang Hospital affiliated to Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Indiana University Richard M. Fairbanks School of Public Health Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Beijing ChaoYang Hospital affiliated to Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Capital Medical University School of Stomatology Beijing 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