{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:26:20Z","timestamp":1784820380006,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Science &Technology, Government of India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the potential of antimicrobial photodynamic therapy (<jats:styled-content style=\"fixed-case\">aPDT<\/jats:styled-content>) as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In a single\u2010centred randomized and controlled clinical trial, 90 patients (51 females and 39 males) with untreated chronic periodontitis were randomly assigned to receive SRP with <jats:styled-content style=\"fixed-case\">aPDT<\/jats:styled-content> (test group) or SRP alone (control group). Clinical parameters and halitosis were recorded for 6\u00a0months after treatment by a periodontist who was blinded to the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inter\u2010group and intra\u2010group statistical analyses were performed. Significant difference between the two groups with respect to each variable was assessed using non\u2010parametric Rank Order <jats:sc>ancova<\/jats:sc>. Probing pocket depth and clinical attachment levels showed statistically significant reduction in the test group on evaluation at 3\u00a0months and 6\u00a0months as compared to the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). A statistically significant improvement in gingival index and gingival bleeding index was seen for the test group after 2\u00a0weeks and 1\u00a0month of <jats:styled-content style=\"fixed-case\">aPDT<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), whereas the improvement in gingival index and gingival bleeding index at 3\u00a0months and in plaque index at 2\u00a0weeks after <jats:styled-content style=\"fixed-case\">aPDT<\/jats:styled-content> was less (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Also, a significant difference was detected for the test group at 1\u00a0month in terms of halitosis (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), which did not persist for long.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antimicrobial photodynamic therapy acts as a beneficial adjunct to SRP in non\u2010surgical treatment and management of chronic periodontitis in short\u2010term. Further studies are required to assess the long\u2010term effectiveness of <jats:styled-content style=\"fixed-case\">aPDT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12249","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T08:50:19Z","timestamp":1394614219000},"page":"573-581","source":"Crossref","is-referenced-by-count":121,"title":["Efficacy of antimicrobial photodynamic therapy in the management of chronic periodontitis: a randomized controlled clinical trial"],"prefix":"10.1111","volume":"41","author":[{"given":"Joseph","family":"Betsy","sequence":"first","affiliation":[{"name":"Department of Periodontics Government Dental College Thiruvananthapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra S.","family":"Prasanth","sequence":"additional","affiliation":[{"name":"Biophotonics Laboratory Centre for Earth Science Studies Thiruvananthapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamalasanan V.","family":"Baiju","sequence":"additional","affiliation":[{"name":"Department of Statistics Government Women's College Thiruvananthapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janam","family":"Prasanthila","sequence":"additional","affiliation":[{"name":"Department of Periodontics Government Dental College Thiruvananthapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanan","family":"Subhash","sequence":"additional","affiliation":[{"name":"Biophotonics Laboratory Centre for Earth Science Studies Thiruvananthapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.03676.x"},{"key":"e_1_2_8_3_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u20101426\u2010y"},{"key":"e_1_2_8_5_1","first-page":"34","article-title":"Treatment of periodontal disease by photo disinfection compared to scaling and root planing","volume":"18","author":"Andersen R.","year":"2007","journal-title":"The Journal of Clinical Dentistry"},{"key":"e_1_2_8_6_1","first-page":"532","article-title":"Nonsurgical treatment of aggressive periodontitis with photodynamic therapy or systemic antibiotics","volume":"123","author":"Arweiler N. 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