{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:46:22Z","timestamp":1777607182183,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001827","name":"University of Amsterdam","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001827","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["KFO208"],"award-info":[{"award-number":["KFO208"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Dutch Society of Periodontology"},{"name":"German Ministry for Education and Research","award":["01EY1103"],"award-info":[{"award-number":["01EY1103"]}]},{"name":"Helmholtz Zentrum M\u00fcnchen - German Research Center for Environmental Health"},{"name":"German Federal Ministry of Education and Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Identification of variants within genes <jats:italic><jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>23A1<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>23A2<\/jats:italic> coding for vitamin C transporter proteins associated with aggressive (AgP) and chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Employment of three independent case\u2013control samples of AgP (I. 283 cases, 979 controls; <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. 417 cases, 1912 controls; <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>. 164 cases, 357 controls) and one sample of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> (1359 cases, 1296 controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stage 1: Among the tested single\u2010nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s), the rare allele (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) of rs6596473 in <jats:italic><jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>23A1<\/jats:italic> showed nominal significant association with AgP (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.026, odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 1.26, and a highly similar minor allele frequency between different control panels. Stage 2: rs6596473 showed no significant association with AgP in the replication with the German and Dutch case\u2013control samples. After pooling the German AgP populations (674 cases, 2891 controls) to significantly increase the statistical power (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u00a0=\u00a00.81), rs6596473 <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> showed significant association with AgP prior to and upon adjustment with the covariates smoking and gender with p<jats:sub>adj<\/jats:sub>\u00a0=\u00a00.005, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.35. Stage 3: <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> of rs6596473 showed no significant association with severe <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> rs6596473 of <jats:italic><jats:styled-content style=\"fixed-case\">SLC<\/jats:styled-content>23A1<\/jats:italic> is suggested to be associated with AgP. These results add to previous reports that vitamin C plays a role in the pathogenesis of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12253","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T13:22:35Z","timestamp":1396876955000},"page":"531-540","source":"Crossref","is-referenced-by-count":28,"title":["<i><scp>SLC<\/scp>23A1<\/i> polymorphism rs6596473 in the vitamin C transporter <scp>SVCT<\/scp>1 is associated with aggressive periodontitis"],"prefix":"10.1111","volume":"41","author":[{"given":"Thijs M. H.","family":"de Jong","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Biochemistry Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-2843","authenticated-orcid":false,"given":"Arne","family":"Jochens","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics and Statistics Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Jockel\u2010Schneider","sequence":"additional","affiliation":[{"name":"Department of Periodontology Clinic of Preventive Dentistry and Periodontology University Medical Center of the Julius\u2010Maximilians\u2010University W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Harks","sequence":"additional","affiliation":[{"name":"Center of Periodontology, Operative and Preventive Dentistry Clinic of University Medical Center M\u00fcnster Preventive Dentistry M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Dommisch","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Operative and Preventive Dentistry University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Graetz","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Periodontology University Medical Center Schleswig\u2010Holstein Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Flachsbart","sequence":"additional","affiliation":[{"name":"Institute for Clinical Molecular Biology Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingmar","family":"Staufenbiel","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Periodontology and Preventive Dentistry Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Eberhard","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry and Biomedical Material Sciences Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Folwaczny","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry and Periodontology University of Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Noack","sequence":"additional","affiliation":[{"name":"Center of Periodontology, Operative and Preventive Dentistry Clinic of Preventive Dentistry University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Meyle","sequence":"additional","affiliation":[{"name":"Department of Periodontology University Medical Center Giessen and Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Eickholz","sequence":"additional","affiliation":[{"name":"Department of Periodontology Centre for Dental, Oral and Maxillofacial Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gieger","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health Neuherberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Grallert","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health Neuherberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Lieb","sequence":"additional","affiliation":[{"name":"Biobank popgen University Medical Center Schleswig\u2010Holstein Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Franke","sequence":"additional","affiliation":[{"name":"Institute for Clinical Molecular Biology Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almut","family":"Nebel","sequence":"additional","affiliation":[{"name":"Institute for Clinical Molecular Biology Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Institute for Clinical Molecular Biology Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"Doerfer","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Periodontology University Medical Center Schleswig\u2010Holstein Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Operative and Preventive Dentistry University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinna","family":"Bruckmann","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology Clinic of Dentistry Bernhard Gottlieb University Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubele","family":"van der Velden","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Biochemistry Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno G.","family":"Loos","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Biochemistry Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne S.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Institute for Clinical Molecular Biology Christian\u2010Albrechts\u2010University Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01053.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00643.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027001061.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041000112"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314597"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.3.657"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp076"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(98)00037-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj035"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635580802033110"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.6.1113s"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.1.23"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/17.7.654"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290311.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01927.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00955.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01054.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.110.000109"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001213"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345880670051201"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2011.06.008"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.7.651"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12092"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000378"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.75"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp508"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002816"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.9.e20"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29438"},{"key":"e_1_2_6_32_1","first-page":"51","article-title":"Periodontal health related to plasma ascorbic acid","volume":"89","author":"V\u00e4\u00e4n\u00e4nen M. K.","year":"1993","journal-title":"Proceedings of the Finnish Dental Society"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00953.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01663.x"},{"key":"e_1_2_6_35_1","unstructured":"WHO(2003)Diet nutrition and the prevention of chronic diseases.http:\/\/www.who.int\/dietphysicalactivity\/publications\/trs916\/en\/gsfao_dental.pdf."},{"key":"e_1_2_6_36_1","first-page":"44","article-title":"Ascorbic acid and periodontal disease: a review of the literature","volume":"28","author":"Woolfe S. N.","year":"1980","journal-title":"The Journal of the Western Society of Periodontology\/Periodontal Abstracts"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.01.027"},{"key":"e_1_2_6_38_1","first-page":"2997","article-title":"Association between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean population","volume":"17","author":"Zanon\u2010Moreno V.","year":"2011","journal-title":"Molecular Vision"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12253","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:12:51Z","timestamp":1696259571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/jcpe.12253"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12253","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]}}}