{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:44:04Z","timestamp":1779392644819,"version":"3.53.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DGParo-GABA"},{"name":"doctoral scholarship of the Landeszahn\u00ef\u00bf\u00bdrztekammer Hessen (Dentists Chamber of Hassia)"},{"name":"Octapharma, Langenfeld, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Von <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>illebrand disease (<jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>) is the most common inherent bleeding disorder resulting in prolonged bleeding time. Gingival bleeding is a frequently reported symptom of <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>. However, gingival bleeding is also known as a leading symptom of plaque\u2010induced gingivitis and untreated periodontal disease. Gingival bleeding in <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> patients (<jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>) may be triggered by gingival inflammation and not a genuine symptom. Thus, this study evaluated whether type 1 <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> determines an increased susceptibility to gingival bleeding in response to the oral biofilm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty cases and 40 controls were examined haematologically (<jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> antigen, <jats:styled-content style=\"fixed-case\">VWF R<\/jats:styled-content>istocetin cofactor, factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> activity) and periodontally [<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ingival <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>leeding <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">GBI<\/jats:styled-content>), bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>laque <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ontrol <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ecord (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>), periodontal inflamed surface area (<jats:styled-content style=\"fixed-case\">PISA<\/jats:styled-content>), vertical probing attachment level].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GBI<\/jats:styled-content> was significantly higher in controls (12.2%) than in <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> (10%). The study failed to find a significant difference regarding <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> (17%) and controls (17.2%). Multiple regressions identified <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PISA<\/jats:styled-content> to be associated with <jats:styled-content style=\"fixed-case\">GBI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> was negatively associated with <jats:styled-content style=\"fixed-case\">GBI<\/jats:styled-content>. Smoking and number of remaining teeth was negatively associated with <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> is not associated with a more pronounced inflammatory response to the oral biofilm in terms of <jats:styled-content style=\"fixed-case\">GBI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12274","type":"journal-article","created":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T10:34:40Z","timestamp":1399804480000},"page":"766-771","source":"Crossref","is-referenced-by-count":15,"title":["Is gingival bleeding a symptom of patients with type 1 von <scp>W<\/scp>illebrand disease? A case\u2013control study"],"prefix":"10.1111","volume":"41","author":[{"given":"Lisa","family":"Weickert","sequence":"first","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Miesbach","sequence":"additional","affiliation":[{"name":"Haemophilia Centre Medical Clinic III\/Institute for Transfusion Medicine Hospital of the Johann Wolfgang Goethe\u2010University Frankfurt\/Main Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja Rosa","family":"Alesci","sequence":"additional","affiliation":[{"name":"Haemophilia Centre Medical Clinic III\/Institute for Transfusion Medicine Hospital of the Johann Wolfgang Goethe\u2010University Frankfurt\/Main Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eickholz","sequence":"additional","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Nickles","sequence":"additional","affiliation":[{"name":"Department of Periodontology Center for Dentistry and Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"87","article-title":"Gingival bleeding as a presenting symptom in Von\u2010Willebrands\u2019 disease\u2013review of literature and report of cases","volume":"35","author":"Abbas K. 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