{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:12Z","timestamp":1787015472604,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2013\/01072-5"],"award-info":[{"award-number":["2013\/01072-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To evaluate the clinical and microbiological effects of the use of metronidazole (\n                      <jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>\n                      )\u00a0+\u00a0amoxicillin (\n                      <jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>\n                      ) as adjuncts to scaling and root planing (\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      ) for the treatment of chronic periodontitis (ChP) in type 2 diabetic subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010eight type 2 diabetic subjects (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a029\/group) with generalized ChP were randomly assigned to receive SRP alone or with MTZ [400\u00a0mg\/thrice a day (TID)]+AMX (500\u00a0mg\/TID) for 14\u00a0days. Subgingival biofilm samples were analyzed by\n                      <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>\n                      for the presence of seven periodontal pathogens. Subjects were monitored at baseline, 3, 6 and 12\u00a0months post\u2010therapies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The group receiving\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      +\n                      <jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>\n                      +\n                      <jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>\n                      presented greater mean probing depth (\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      ) reduction and clinical attachment gain, a lower number of sites with\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      \u22655\u00a0mm (primary outcome variable) and a reduced number of subjects with \u22659 of these residual pockets than the control group at 1\u2010year post\u2010therapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The antibiotic\u2010treated group also presented reduced levels and greater decreases of the three red complex species,\n                      <jats:italic>Eubacterium nodatum<\/jats:italic>\n                      and\n                      <jats:italic>Prevotella intermedia,<\/jats:italic>\n                      compared to the control group at 1\u00a0year (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The adjunctive use of\n                      <jats:styled-content style=\"fixed-case\">MTZ<\/jats:styled-content>\n                      +\n                      <jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>\n                      significantly improved the clinical and microbiological outcomes of\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      in the treatment of type 2 diabetic subjects with ChP.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12282","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T13:48:58Z","timestamp":1402667338000},"page":"890-899","source":"Crossref","is-referenced-by-count":75,"title":["Metronidazole and amoxicillin as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1\u2010year outcomes of a randomized placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"41","author":[{"given":"Tamires Szeremeske","family":"Miranda","sequence":"first","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Feres","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Juliana","family":"Perez\u2010Chaparro","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Faveri","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene Cristina","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neila Sumie","family":"Tamashiro","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Ferreira","family":"Bastos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poliana Mendes","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1515\/dmdi-2012-0003","article-title":"Local concentration of systemic amoxicillin and metronidazole in healthy and inflamed gingiva: a comparative in vivo study","volume":"10","author":"Amid R.","year":"2012","journal-title":"Drug Metabolism and Drug Interactions"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12080"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/jre.12058","article-title":"Effects of periodontal non\u2010surgical therapy plus azithromycin on glycemic control in patients with diabetes: a randomized clinical trial","volume":"48","author":"Botero J. 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