{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:12:03Z","timestamp":1781583123587,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Government of Pakistan","doi-asserted-by":"crossref","award":["20-685"],"award-info":[{"award-number":["20-685"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Government of Pakistan","doi-asserted-by":"crossref","award":["R& D 06\/1959"],"award-info":[{"award-number":["R& D 06\/1959"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Few studies have examined the relationship of individual periodontal parameters with individual systemic biomarkers. This study assessed the possible association between specific clinical parameters of periodontitis and systemic biomarkers of coronary heart disease risk in coronary heart disease patients with periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Angiographically proven coronary heart disease patients with periodontitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a0317), aged &gt;30\u00a0years and without other systemic illness were examined. Periodontal clinical parameters of bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>), probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), and clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) and systemic levels of high\u2010sensitivity C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), fibrinogen (<jats:styled-content style=\"fixed-case\">FIB<\/jats:styled-content>) and white blood cells (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) were noted and analyzed to identify associations through linear and stepwise multiple regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unadjusted linear regression showed significant associations between periodontal and systemic parameters; the strongest association (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.629; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) was found between <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels, the periodontal and systemic inflammation marker, respectively. Stepwise regression analysis models revealed that <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> was a predictor of systemic <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> was the only periodontal parameter significantly associated with each systemic parameter (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FIB<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In coronary heart disease patients with periodontitis, <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> is strongly associated with systemic <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels; this association possibly reflects the potential significance of the local periodontal inflammatory burden for systemic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12284","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T16:55:35Z","timestamp":1403196935000},"page":"1048-1054","source":"Crossref","is-referenced-by-count":47,"title":["Periodontitis in coronary heart disease patients: strong association between bleeding on probing and systemic biomarkers"],"prefix":"10.1111","volume":"41","author":[{"given":"Syed Akhtar H.","family":"Bokhari","sequence":"first","affiliation":[{"name":"The University of Faisalabad Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayyaz A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Sheikh Zayed Federal Postgraduate Medical Institute &amp; Hospital Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshad 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