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Clinical assessments were recorded at baseline, 3 and 6\u00a0months after therapy and included clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>), set as the primary outcome of the study, probing pocket depth (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>), recession (<jats:styled-content style=\"fixed-case\">RE<\/jats:styled-content>) and bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>). At the same time points, counts of 15 subgingival species were evaluated by \u201ccheckerboard\u201d <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> hybridization, gingival crevicular fluid samples were analysed for matrix metalloproteinase\u20108 (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108) by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> and HbA1c levels were determined. Comparisons between and within groups were performed by non\u2010parametric tests (Mann\u2013Whitney, Wilcoxon signed\u2010ranks and <jats:italic>z<\/jats:italic>\u2010test for proportions with Bonferroni corrections) at the 0.05 level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No major differences were noticed in clinical and microbiological parameters of periodontal disease or levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20108 between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adjunctive systemic doxycycline does not seem to significantly enhance the effects of <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> in well\u2010controlled diabetes type 2 patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12287","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T15:36:52Z","timestamp":1404920212000},"page":"972-980","source":"Crossref","is-referenced-by-count":37,"title":["Effects of doxycycline on clinical, microbiological and immunological parameters in well\u2010controlled diabetes type\u20102 patients with periodontal disease: a randomized, controlled clinical trial"],"prefix":"10.1111","volume":"41","author":[{"given":"Lazaros","family":"Tsalikis","sequence":"first","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology School of Dentistry Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Sakellari","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology School of Dentistry Aristotle University of 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