{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:11:21Z","timestamp":1792138281680,"version":"4.4.0"},"reference-count":70,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation - FAPESP, Brazil","award":["2010\/16162-1"],"award-info":[{"award-number":["2010\/16162-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the association among serum immunoglobulin G (IgG) responses to <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (<jats:italic>Aa<\/jats:italic>) serotypes a, b and c, <jats:italic>Porphyromonas gingivalis<\/jats:italic> (<jats:italic>Pg<\/jats:italic>), <jats:italic>Tannerella forsythia<\/jats:italic> (<jats:italic>Tf<\/jats:italic>) and clinical parameters in Aggressive Periodontitis (<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>) subjects. Associations between periodontal pathogens and clinical and immunological parameters were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight subjects diagnosed with generalized <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>) and localized <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content>) were included. Ten healthy controls were also evaluated. Clinical parameters were assessed and percentages of subgingival levels of <jats:italic>Aa<\/jats:italic>,<jats:italic> Pg<\/jats:italic> and <jats:italic>Tf<\/jats:italic> (beyond bacterial load)<jats:italic>,<\/jats:italic> were determined by quantitative real\u2010time polymerase chain reaction. Serum IgG antibody levels against <jats:italic>Aa<\/jats:italic>,<jats:italic> Pg<\/jats:italic> and <jats:italic>Tf<\/jats:italic> were evaluated by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Percentages of <jats:italic>Aa<\/jats:italic>,<jats:italic> Pg<\/jats:italic> and <jats:italic>Tf<\/jats:italic> were significantly higher in <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> than in controls. The response to Aa serotype c was higher in <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> subjects than in controls. There were no differences in microbial composition or antibodies responses between <jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content>, except for IgG response to <jats:italic>Tf<\/jats:italic>. <jats:italic>Pg<\/jats:italic> levels were correlated with probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), BoP and <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content> but not in <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> subjects. <jats:italic>Tf<\/jats:italic> levels correlated with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content> subjects. In <jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>, the infection levels of <jats:italic>Aa<\/jats:italic> and <jats:italic>Pg<\/jats:italic> correlated with the corresponding IgG levels to Aa serotype c and Pg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the evidences that IgG response in <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> patients correlated with bacterial infection level in <jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>, but not in <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content>, and that <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> patients lack a response to <jats:italic>Tf<\/jats:italic>, despite harbouring this species, our data suggest a difference in host immune defence between these two forms of aggressive periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12296","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T13:25:01Z","timestamp":1406553901000},"page":"943-951","source":"Crossref","is-referenced-by-count":23,"title":["IgG sera levels against a subset of periodontopathogens and severity of disease in aggressive periodontitis patients: a cross\u2010sectional study of selected pocket sites"],"prefix":"10.1111","volume":"41","author":[{"given":"Luciana","family":"Saraiva","sequence":"first","affiliation":[{"name":"Department of Periodontology Dental School University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela S.","family":"Rebeis","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental School University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eder de S.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental School University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo T.","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental School University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen S.","family":"Ando\u2010Suguimoto","sequence":"additional","affiliation":[{"name":"Department of Microbiology Institute of Biomedical Sciences University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo S.","family":"Mafra","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental School University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"Holzhausen","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental School University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe A.","family":"Romito","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental School University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia P. 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