{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:10:50Z","timestamp":1790208650094,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dentaid SL"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study was to evaluate the effect of full\u2010mouth tooth extraction on the oral microflora, with emphasis on the presence and load of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Adult patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a030), with moderate to advanced periodontitis and scheduled for full\u2010mouth tooth extraction, were consecutively selected. Prior to and 1 and 3\u00a0months after full\u2010mouth tooth extraction saliva, tongue, buccal and gingival mucosa and subgingival plaque\/prosthesis samples were obtained. Aerobic and anaerobic culture techniques and quantitative real\u2010time polymerase chain reaction (<jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>) were employed for the detection of oral pathogens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Full\u2010mouth tooth extraction resulted in reduction below detection level of <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> and <jats:italic>P.\u00a0gingivalis<\/jats:italic> in 15 of 16 and 8 of 16 previously positive patients using culture techniques and <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>, respectively. Those patients remaining <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> positive showed a significant reduction in load of these bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Full\u2010mouth tooth extraction significantly changes the oral microflora. These changes include reduction of <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> and <jats:italic>P.\u00a0gingivalis<\/jats:italic>, frequently to levels below detection threshold. In some patients, <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> and <jats:italic>P.\u00a0gingivalis<\/jats:italic> can persist in the edentulous oral cavity up to 3\u00a0months after full\u2010mouth tooth extraction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12297","type":"journal-article","created":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T14:31:42Z","timestamp":1406385102000},"page":"981-989","source":"Crossref","is-referenced-by-count":18,"title":["Changes in oral microflora after full\u2010mouth tooth extraction: a prospective cohort study"],"prefix":"10.1111","volume":"41","author":[{"given":"Yvonne C.M.","family":"de Waal","sequence":"first","affiliation":[{"name":"Center for Dentistry and Oral Hygiene University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin G.","family":"Winkel","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerwin C.","family":"Raangs","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen L.","family":"van der Vusse","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.A.","family":"Rossen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie Jan","family":"van Winkelhoff","sequence":"additional","affiliation":[{"name":"Center for Dentistry and Oral Hygiene University of Groningen University Medical Center Groningen Groningen The Netherlands"},{"name":"Department of Medical Microbiology University of Groningen University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1996.tb00180.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.11.4950-4954.2003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2005.03.011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00925.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080092"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00412.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb01784.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.3.209"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130088"},{"key":"e_1_2_6_12_1","first-page":"262","article-title":"Evaluation of peri\u2010implant microbiota using the polymerase chain reaction in completely edentulous patients before and after placement of implant\u2010supported prostheses submitted to immediate load","volume":"21","author":"Devides S. 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