{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:51:40Z","timestamp":1777999900661,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Periodontal Research Fund of the Eastman Dental Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore whether subjects harbouring <jats:italic>A. actinomycetemcomitans<\/jats:italic>,<jats:italic> P. gingivalis<\/jats:italic> or <jats:italic>T. forsythia<\/jats:italic> at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (<jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MET<\/jats:styled-content>) during non\u2010surgical treatment of generalized aggressive periodontitis (<jats:styled-content style=\"fixed-case\">GAgP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Forty one subjects were included in this 6\u2010month randomized placebo\u2010controlled clinical trial using a 7\u2010day course of systemic <jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MET<\/jats:styled-content> or placebo as adjuncts to non\u2010surgical periodontal therapy. Clinical and microbiological parameters were collected at baseline, 2 and 6\u00a0months after treatment. Microbiological cultures were processed for pooled subgingival samples and identities of isolates were determined by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> for <jats:italic>A. actinomycetemcomitans<\/jats:italic>,<jats:italic> P. gingivalis<\/jats:italic> and <jats:italic>T. forsythia<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6\u00a0months, the test treatment resulted in significant additional improvements in the primary outcome variable compared to placebo, and the effect of the adjunctive antimicrobials was not modified by the baseline microbiological status in the primary analysis. However, secondary exploratory subgroup analyses showed improved clinical outcomes in subjects harbouring <jats:italic>A. actinomycetemcomitans<\/jats:italic> at baseline compared to subjects who did not harbour this pathogen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All subjects benefited from the tested adjunctive antimicrobial regimen, although subjects who harboured <jats:italic>A. actinomycetemcomitans<\/jats:italic> at baseline may show greater clinical benefits. Larger appropriately powered studies are needed to confirm whether adjunctive <jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MET<\/jats:styled-content> is more beneficial for <jats:styled-content style=\"fixed-case\">GAgP<\/jats:styled-content> patients who harbour <jats:italic>A. actinomycetemcomitans,<\/jats:italic> along with other key periodontal pathogens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12299","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T16:05:16Z","timestamp":1408464316000},"page":"1080-1089","source":"Crossref","is-referenced-by-count":37,"title":["Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: an exploratory analysis from a randomized controlled clinical trial"],"prefix":"10.1111","volume":"41","author":[{"given":"Adri\u00e1n","family":"Guerrero","sequence":"first","affiliation":[{"name":"Graduate Periodontology University of Granada and Private Periodontal Practice M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Nibali","sequence":"additional","affiliation":[{"name":"University College London (UCL) Eastman Dental Institute London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Lambertenghi","sequence":"additional","affiliation":[{"name":"University College London (UCL) Eastman Dental Institute London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derren","family":"Ready","sequence":"additional","affiliation":[{"name":"PHL London Public Health England London UK"},{"name":"Department of Microbial Diseases Eastman Dental Institute and Hospital University College London London 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