{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:32:30Z","timestamp":1790382750842,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Coordination of Improvement of Higher Education Personnel"},{"name":"Foundation for Research"},{"DOI":"10.13039\/100000002","name":"The National Institutes of Health","doi-asserted-by":"crossref","award":["DE021565"],"award-info":[{"award-number":["DE021565"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"The National Institutes of Health","doi-asserted-by":"crossref","award":["DE021565"],"award-info":[{"award-number":["DE021565"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"State of Rio de Janeiro"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n To determine microbial profiles that discriminate periodontal health from different forms of periodontal diseases.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Subgingival biofilm was obtained from patients with periodontal health (27), gingivitis (11), chronic periodontitis (35) and aggressive periodontitis (24), and analysed for the presence of >250 species\/phylotypes using\n HOMIM<\/jats:styled-content>\n . Microbial differences among groups were examined by Mann\u2013Whitney\n U<\/jats:italic>\n \u2010test. Regression analyses were performed to determine microbial risk indicators of disease.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Putative and potential new periodontal pathogens were more prevalent in subjects with periodontal diseases than periodontal health. Detection of\n Porphyromonas endodontalis\/Porphyromonas<\/jats:italic>\n spp. (\n OR<\/jats:styled-content>\n 9.5 [1.2\u201373.1]) and\n Tannerella forsythia<\/jats:italic>\n (\n OR<\/jats:styled-content>\n 38.2 [3.2\u2013450.6]), and absence of\n Neisseria polysaccharea<\/jats:italic>\n (\n OR<\/jats:styled-content>\n 0.004 [0\u20130.15]) and\n Prevotella denticola<\/jats:italic>\n (\n OR<\/jats:styled-content>\n 0.014 [0\u20130.49],\n p<\/jats:italic>\n \u00a0<\u00a00.05) were risk indicators of periodontal disease. Presence of\n Aggregatibacter actinomycetemcomitans<\/jats:italic>\n (\n OR<\/jats:styled-content>\n 29.4 [3.4\u2013176.5]),\n Cardiobacterium hominis<\/jats:italic>\n (\n OR<\/jats:styled-content>\n 14.9 [2.3\u201398.7]),\n Peptostreptococcaceae<\/jats:italic>\n sp. (\n OR<\/jats:styled-content>\n 35.9 [2.7\u2013483.9]\n ), P.\u00a0alactolyticus<\/jats:italic>\n (\n OR<\/jats:styled-content>\n 31.3 [2.1\u2013477.2]), and absence of\n Fretibacterium<\/jats:italic>\n spp. (\n OR<\/jats:styled-content>\n 0.024 [0.002\u20130.357]),\n Fusobacterium naviforme\/Fusobacterium nucleatum ss vincentii<\/jats:italic>\n (\n OR<\/jats:styled-content>\n 0.015 [0.001\u20130.223]),\n Granulicatella adiacens\/Granulicatella elegans<\/jats:italic>\n (\n OR<\/jats:styled-content>\n 0.013 [0.001\u20130.233],\n p<\/jats:italic>\n \u00a0<\u00a00.05) were associated with aggressive periodontitis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n There were specific microbial signatures of the subgingival biofilm that were able to distinguish between microbiomes of periodontal health and diseases. Such profiles may be used to establish risk of disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpe.12302","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T12:06:49Z","timestamp":1408450009000},"page":"1027-1036","source":"Crossref","is-referenced-by-count":165,"title":["Microbial signature profiles of periodontally healthy and diseased patients"],"prefix":"10.1111","volume":"41","author":[{"given":"Talita Gomes Ba\u00eata","family":"Louren\u00e7o","sequence":"first","affiliation":[{"name":"Institute of Microbiology Federal University of Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Heller","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Federal University of Rio de Janeiro Brazil"},{"name":"Department of Dental Clinic Division of Graduate Periodontics Federal University of Rio de Janeiro Brazil"},{"name":"Oral Biology Department Goldman School of Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina Maciel","family":"Silva\u2010Boghossian","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Federal University of Rio de Janeiro Brazil"},{"name":"Department of Dental Clinic Division of Graduate Periodontics Federal University of Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean L.","family":"Cotton","sequence":"additional","affiliation":[{"name":"Department of Microbiology The Forsyth Institute Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Paster","sequence":"additional","affiliation":[{"name":"Department of Microbiology The Forsyth Institute Cambridge MA USA"},{"name":"Harvard School of Dental Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Vieira","family":"Colombo","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Federal University of Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.11.5721-5732.2005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.174"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00353.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12190"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.30"},{"key":"e_1_2_7_9_1","first-page":"260","article-title":"The human microbiome: At the interface of health and disease","volume":"13","author":"Cho I.","year":"2012","journal-title":"Nature"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110566"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090185"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2337"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00542-10"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.4.2837-2848.2006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00729-13"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065520"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085066"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.191"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02454.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-11-33"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01701.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808701104"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071227"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.66.3.486-505.2002"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.3944-3955.2005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00317-06"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037919"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12167"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.12.3770-3783.2001"},{"key":"e_1_2_7_30_1","first-page":"257","article-title":"A new taxon in the Genus Neisseria","volume":"134","author":"Riou J. 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