{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:48:53Z","timestamp":1760888933251},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Council for Scientific and Technological Developmen"},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES), Brasilia, Brazil"},{"name":"Foundation for Research Support of Rio de Janeiro State (FAPERJ), Rio de Janeiro, Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The aims of the current study were to compare the levels of HIV<\/jats:styled-content>\u20101 in the subgingival biofilm (SHVL<\/jats:styled-content>) between detectable and undetectable plasmatic HIV<\/jats:styled-content>\u20101 viral load (PHVL<\/jats:styled-content>) in HIV<\/jats:styled-content>\u2010infected patients as well as to determine the association of SHVL<\/jats:styled-content> with PHVL<\/jats:styled-content> and clinical periodontal parameters.<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>Forty\u2010one HIV<\/jats:styled-content>\u2010infected individuals were divided into two groups: detectable (21) and undetectable (20) PHVL<\/jats:styled-content>. Subgingival biofilm samples were obtained for detection and quantification of HIV<\/jats:styled-content>\u20101 by real\u2010time RT<\/jats:styled-content>\u2010PCR<\/jats:styled-content>. To estimate the effect of co\u2010variables on the outcome undetectable SHVL<\/jats:styled-content>, the Generalized Estimation Equation (GEE<\/jats:styled-content>) was employed.<\/jats:p><\/jats:sec>Results<\/jats:title>Detectable SHVL<\/jats:styled-content> was observed only in the detectable PHVL<\/jats:styled-content> group and the detection of the HIV<\/jats:styled-content>\u20101 was observed in 40% of these individuals. In the bivariate analysis between co\u2010variables from the individual level and the outcome SHVL<\/jats:styled-content>, significant difference was observed only for the CD<\/jats:styled-content>4+ T lymphocytes levels (p<\/jats:italic>\u00a0=\u00a00.017). The multiple logistic model demonstrated that only CD<\/jats:styled-content>4+ T lymphocytes levels had a significant effect on the outcome undetectable SHVL<\/jats:styled-content> [OR<\/jats:styled-content> 8.85 (CI<\/jats:styled-content> 3.6\u20139.2), p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.002].<\/jats:p><\/jats:sec>Conclusion<\/jats:title>HIV<\/jats:styled-content>\u20101 can be detected and quantified in the subgingival biofilm of HIV<\/jats:styled-content>\u2010infected individuals, but these findings are not associated with PHVL<\/jats:styled-content> and periodontal clinical parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12306","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T04:19:11Z","timestamp":1410149951000},"page":"1061-1068","source":"Crossref","is-referenced-by-count":6,"title":["Levels of HIV\u20101 in subgingival biofilm of HIV\u2010infected patients"],"prefix":"10.1111","volume":"41","author":[{"given":"Priscila","family":"Pavan","sequence":"first","affiliation":[{"name":"Department of Dental Clinics Division of Graduate Periodontics School of Dentistry Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane Tiago","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Dental Clinics Division of Graduate Periodontics School of Dentistry Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Carvalho","family":"Souza","sequence":"additional","affiliation":[{"name":"Dental School Est\u00e1cio de S\u00e1 University Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso Oliveira","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Dental Clinics Division of Graduate Periodontics School of Dentistry Rio de Janeiro 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