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Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>This report documents a case of dramatic bisphosphonate\u2010related osteonecrosis associated with periodontitis and dental implant removal in an osteoporotic patient treated with <jats:italic>per os<\/jats:italic> bisphosphonates for an uninterrupted period of 15\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The aim of this report was to discuss the administration period of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in the treatment of osteoporosis, the decision\u2010making and clinical management of severe <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> and the indications for dental implant placement in these specific patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12322","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T11:42:29Z","timestamp":1413632549000},"page":"190-195","source":"Crossref","is-referenced-by-count":19,"title":["Dramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis, and dental implant removal"],"prefix":"10.1111","volume":"42","author":[{"given":"Alberto","family":"Fern\u00e1ndez Ayora","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Surgery Faculty of Medicine University of Liege Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Herion","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Surgery Faculty of Medicine University of Liege Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rompen","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Surgery Faculty of Medicine University of Liege Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Yves","family":"Reginster","sequence":"additional","affiliation":[{"name":"Department of Public Health Epidemiology and Health Economics Faculty of Medicine University of Liege Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Magremanne","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Faculty of Medicine and Dentistry Universit\u00e9 Catholique de Louvain Louvain Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Surgery CHU of Li\u00e8ge Li\u00e8ge Belgium"},{"name":"Dental Biomaterials Research Unit (DBRU) Faculty of Medicine University of Liege Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0355"},{"key":"e_1_2_5_3_1","unstructured":"American Association of Oral and Maxillofacial Surgeons(2014)American Association of Oral and Maxillofacial Surgeons position paper. 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