{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:10Z","timestamp":1787015350981,"version":"build-2736575974"},"reference-count":79,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Unit of Dentistry and Oral Surgery of the University of Pisa"},{"name":"Italian Ministry Health"},{"name":"Tuscan Region","award":["# GR-2009-1592229"],"award-info":[{"award-number":["# GR-2009-1592229"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n To systematically review the performance of access flap (\n OFD<\/jats:styled-content>\n ) in the treatment of class\n II<\/jats:styled-content>\n furcation defects (\n FD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n RCT<\/jats:styled-content>\n s evaluating surgical treatment of class\n II FD<\/jats:styled-content>\n with\n OFD<\/jats:styled-content>\n , minimum 6\u00a0months follow\u2010up were identified. Screening, data extraction, and quality assessment were conducted independently by three reviewers. The primary outcomes were tooth survival and change in the horizontal clinical attachment level (\n HCAL<\/jats:styled-content>\n ). Changes in vertical clinical attachment level (\n VCAL<\/jats:styled-content>\n ), reduction of pocket probing depth (\n PPD<\/jats:styled-content>\n ), recession increase (\n REC<\/jats:styled-content>\n ), horizontal (\n HBL<\/jats:styled-content>\n ), and vertical bone level (\n VBL<\/jats:styled-content>\n ) were also collected.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The search identified 1571 studies out of which 11 articles met the inclusion criteria. Data analysis was performed on 199 patients and 251\n FD<\/jats:styled-content>\n . Tooth survival was seldom reported. Altogether with inflammatory amelioration, the weighted mean differences were for\n HCAL<\/jats:styled-content>\n 0.96\u00a0mm [\n CI<\/jats:styled-content>\n : (0.60, 1.32),\n p<\/jats:italic>\n \u00a0<\u00a00.001], 0.55\u00a0mm [\n CI<\/jats:styled-content>\n : (0.00, 1.10),\n p<\/jats:italic>\n \u00a0=\u00a00.05] for\n VCAL<\/jats:styled-content>\n gain.\n PPD<\/jats:styled-content>\n reduction over 6\u00a0months was 1.38\u00a0mm [\n CI<\/jats:styled-content>\n : (0.91, 1.85),\n p<\/jats:italic>\n \u00a0<\u00a00.01]. Potential risk of bias was identified.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Teeth with mandibular class\n II<\/jats:styled-content>\n furcation involvement treated with\n OFD<\/jats:styled-content>\n show significant clinical improvements 6\u00a0months after surgery. Nevertheless, in order to better understand the magnitude of these changes and their clinical relevance, prospective long\u2010term trials are needed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpe.12327","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T11:17:25Z","timestamp":1414754245000},"page":"169-181","source":"Crossref","is-referenced-by-count":34,"title":["Clinical performance of access flap in the treatment of class\n II<\/scp>\n furcation defects. A systematic review and meta\u2010analysis of randomized clinical trials"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-7306","authenticated-orcid":false,"given":"Filippo","family":"Graziani","sequence":"first","affiliation":[{"name":"Department of surgery Unit of Dentistry and Oral Surgery University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gennai","sequence":"additional","affiliation":[{"name":"Department of surgery Unit of Dentistry and Oral Surgery University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Karapetsa","sequence":"additional","affiliation":[{"name":"Department of surgery Unit of Dentistry and Oral Surgery University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Rosini","sequence":"additional","affiliation":[{"name":"Department of surgery Unit of Dentistry and Oral Surgery University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Filice","sequence":"additional","affiliation":[{"name":"Department of surgery Unit of Dentistry and Oral Surgery University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Gabriele","sequence":"additional","affiliation":[{"name":"Department of surgery Unit of Dentistry and Oral Surgery University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Tonetti","sequence":"additional","affiliation":[{"name":"European Research Group on Periodontology Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2001.280803.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.4.384"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00563.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00220.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.12.1193"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-4-200802190-00008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1979.50.1.23"},{"key":"e_1_2_5_9_1","first-page":"443","article-title":"Guided tissue regeneration in Class II furcation defects using a resorbable polylactic acid barrier","volume":"17","author":"Bremm L. 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