{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:14:07Z","timestamp":1771067647377,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T00:00:00Z","timestamp":1417132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Health Technology R&D Project"},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["A120822"],"award-info":[{"award-number":["A120822"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The objective of study was to determine the osteogenic potential of bone morphogenetic protein\u20102 (<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102) loaded onto a particulate porcine bone mineral (<jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content>) biomaterial using a sinus augmentation model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Release kinetics of <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> was determined in vitro. Eight rabbits received <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> alone into contra\u2010lateral sinus sites. The animals were killed following a 2\u2010week healing interval for micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and histometrical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Approximately 40% of the <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102 was released from <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> over the first 3\u00a0days in vitro; release maintained at a reduced level through day 21. In vivo, total augmented implant volume did not differ significantly between treatments. However, local bone formation was enhanced in the <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102\/<jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> group compared with <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> control (10.5% <jats:italic>versus<\/jats:italic> 6.6%; <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03), specifically in the central aspect of the <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> implant (14.2% <jats:italic>versus<\/jats:italic> 5.5%; <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01) and adjoining the Schneiderian membrane (11.9% <jats:italic>versus<\/jats:italic> 5.0%; <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). There were no significant overall differences in residual biomaterial and fibrovascular tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bone morphogenetic protein\u20102 enhanced local bone formation in the rabbit maxillary sinus model following implantation using a <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content> carrier.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12329","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T08:05:48Z","timestamp":1415174748000},"page":"81-88","source":"Crossref","is-referenced-by-count":23,"title":["Pre\u2010clinical evaluation of the osteogenic potential of bone morphogenetic protein\u20102 loaded onto a particulate porcine bone biomaterial"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-6898","authenticated-orcid":false,"given":"Jeyoung","family":"Yon","sequence":"first","affiliation":[{"name":"Department of 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